Title:
IMPROVED DNA VACCINE FOR SARS-CoV-2
Document Type and Number:
WIPO Patent Application WO/2022/071513
Kind Code:
A1
Abstract:
Provided is DNA that: encodes a coronavirus (SARS CoV-2) spike protein or a fragment thereof; and has been optimized to partially or fully exhibit a codon included in a DNA sequence.
Inventors:
NAKAGAMI HIRONORI (JP)
MORISHITA RYUICHI (JP)
HAYASHI HIROKI (JP)
AMAISHI YASUNORI (JP)
OKAMOTO SACHIKO (JP)
MINENO JUNICHI (JP)
IKAI HISATO (JP)
MICHIBATA JUNKO (JP)
KOMATSUNO TAKAO (JP)
MORISHITA RYUICHI (JP)
HAYASHI HIROKI (JP)
AMAISHI YASUNORI (JP)
OKAMOTO SACHIKO (JP)
MINENO JUNICHI (JP)
IKAI HISATO (JP)
MICHIBATA JUNKO (JP)
KOMATSUNO TAKAO (JP)
Application Number:
PCT/JP2021/036255
Publication Date:
April 07, 2022
Filing Date:
September 30, 2021
Export Citation:
Assignee:
UNIV OSAKA (JP)
TAKARA BIO INC (JP)
ANGES INC (JP)
TAKARA BIO INC (JP)
ANGES INC (JP)
International Classes:
A61K39/215; A61K31/711; A61K35/76; A61K39/39; A61P31/14; C12N15/50; C12N15/63; C12N15/86
Domestic Patent References:
| WO2018074558A1 | 2018-04-26 | |||
| WO2014034735A1 | 2014-03-06 | |||
| WO2018075980A1 | 2018-04-26 | |||
| WO2018189522A1 | 2018-10-18 | |||
| WO2004059556A2 | 2004-07-15 | |||
| WO2007102578A1 | 2007-09-13 | |||
| WO2012144446A1 | 2012-10-26 |
Foreign References:
| RU2731342C1 | 2020-09-01 | |||
| CN112575008A | 2021-03-30 |
Other References:
DATABASE GenBank NCBI; . . : "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome", XP055919172
FUMI KUBOTA: "President AnGes Yamada reveals the development status of the new corona DNA vaccine", BIO.NIKKEIBP.CO, BIO.NIKKEIBP.CO, 27 March 2020 (2020-03-27), XP055919179, Retrieved from the Internet [retrieved on 20220509]
JOURNAL OF GENERAL BIOLOGY, vol. 86, 2005, pages 2269 - 2274
"GeneBank", Database accession no. NC_045512
PATHOGEN, vol. 9, 2020, pages 324
"2P mutations", BIORXIV, 11 June 2020 (2020-06-11)
NUCLEIC ACIDS RES., vol. 30, 2002, pages e43
FUMI KUBOTA: "President AnGes Yamada reveals the development status of the new corona DNA vaccine", BIO.NIKKEIBP.CO, BIO.NIKKEIBP.CO, 27 March 2020 (2020-03-27), XP055919179, Retrieved from the Internet
JOURNAL OF GENERAL BIOLOGY, vol. 86, 2005, pages 2269 - 2274
"GeneBank", Database accession no. NC_045512
PATHOGEN, vol. 9, 2020, pages 324
"2P mutations", BIORXIV, 11 June 2020 (2020-06-11)
NUCLEIC ACIDS RES., vol. 30, 2002, pages e43
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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