Title:
IGF-1 PRODUCTION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2014/103410
Kind Code:
A1
Abstract:
An IGF-1 production promoter comprises, as an active ingredient: a Citrus depressa Hayata extract, preferably water and/or organic solvent extract of Citrus depressa Hayata fruit or leaves, a supercritical extract of Citrus depressa Hayata fruit or leaves, or a subcritical extract of Citrus depressa Hayata fruit or leaves, the Citrus depressa Hayata extract containing 0.3 mass% or more of polymethoxyflavonoid in solid basis, for example, a Citrus depressa Hayata extract containing 0.2 mass% or more of nobiletin and/or 0.1 mass% or more of tangeretin in solid basis; or polymethoxyflavonoid, such as nobiletin or tangeretin.
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Inventors:
OSHIO KAZUTAKA (JP)
NAKAMURA HIROHIKO (JP)
SAKATA YASUYUKI (JP)
NAKAMURA HIROHIKO (JP)
SAKATA YASUYUKI (JP)
Application Number:
PCT/JP2013/067866
Publication Date:
July 03, 2014
Filing Date:
June 28, 2013
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO LTD (JP)
International Classes:
A23L1/30; A61K31/352; A61K36/00; A61K36/75; A61K47/40; A61P21/00; A61P43/00
Domestic Patent References:
| WO2013099982A1 | 2013-07-04 | |||
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Other References:
CHENG Z. ET AL: "TANGERETIN AND ITS METABOLITE 4?-HYDROXYTETRAMETHOXYFLAVONE ATTENUATE EGF-STIMULATED CELL CYCLE PROGRESSION IN HEPATOCYTES; ROLE OF INHIBITION AT THE LEVEL OF MTOR/P70S6K", BRITISH JOURNAL OF PHARMACOLOGY, vol. 162, no. 8, April 2011 (2011-04-01), pages 1781 - 1791, XP055263473
BURNETT, P.E ET AL., PNAS, vol. 95, 1998, pages 1432 - 1437
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KOGA, N. ET AL., BIOL. PHARM. BULL., vol. 30, no. 12, 2007, pages 2317 - 2312
CELL MOL. NEUROBIOL., 30 April 2010 (2010-04-30), pages 347 - 60
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See also references of EP 2939672A4
BURNETT, P.E ET AL., PNAS, vol. 95, 1998, pages 1432 - 1437
ISOTANI, S. ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 33493 - 34498
GINGRAS, A-C. ET AL., GENES & DEV., vol. 15, 2001, pages 807 - 826
FINGAR, D.C.; BLENIS, J., ONCOGENE, vol. 23, 2004, pages 3151 - 3171
EXP. CELL RES., vol. 253, no. 1, 1999, pages 100 - 109
PARTLOW, L.M.; LARRABEE, M.G., J. NEUROCHEM., vol. 18, 1971, pages 2101 - 2118
KOGA, N. ET AL., BIOL. PHARM. BULL., vol. 30, no. 12, 2007, pages 2317 - 2312
CELL MOL. NEUROBIOL., 30 April 2010 (2010-04-30), pages 347 - 60
BRAIN RES., vol. 1303, 15 December 2009 (2009-12-15), pages 179 - 94
CLIN. ENDOCRINOL. (OXF, vol. 63, 2005, pages 470 - 476
CIRCULATION, vol. 110, 2004, pages 2260 - 2265
J. SURG. RES., vol. 145, 2008, pages 279 - 286
INT. J. BIOCHEM. CELL BIOL., vol. 37, no. 10, October 2005 (2005-10-01), pages 1974 - 84
ANN. DERMATOL., vol. 24, no. 1, February 2012 (2012-02-01), pages 26 - 31
See also references of EP 2939672A4
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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