Title:
IL-1 BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2012/088094
Kind Code:
A3
Abstract:
The present invention describes IL-1α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1α. Binding proteins of the invention have high affinity for IL-1α and neutralize IL-1α activity. A binding protein of the invention can be a full-length antibody or an IL-1α -binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1α binding proteins of the invention are useful for detecting IL-1α and for inhibiting IL-1α activity, including in a human subject suffering from a disease or disorder in which IL-1α activity is detrimental.
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Inventors:
HSIEH CHUNG-MING (US)
Application Number:
PCT/US2011/066126
Publication Date:
October 04, 2012
Filing Date:
December 20, 2011
Export Citation:
Assignee:
ABBOTT LAB (US)
HSIEH CHUNG-MING (US)
HSIEH CHUNG-MING (US)
International Classes:
C07K16/24; A61K47/48
Domestic Patent References:
| WO2010087972A2 | 2010-08-05 | |||
| WO2007024715A2 | 2007-03-01 |
Foreign References:
| US20100047239A1 | 2010-02-25 | |||
| US20090215992A1 | 2009-08-27 | |||
| US20110165063A1 | 2011-07-07 |
Other References:
HOLT L J ET AL: "Domain antibodies: proteins for therapy", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 11, 1 November 2003 (2003-11-01), pages 484 - 490, XP004467495, ISSN: 0167-7799, DOI: 10.1016/J.TIBTECH.2003.08.007
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933, DOI: 10.1016/S1380-2933(96)00045-0
WU CHENGBIN ET AL: "Molecular construction and optimization of anti-human IL-1 alpha/beta dual variable domain immunoglobulin (DVD-Ig (TM)) molecules", MABS, LANDES BIOSCIENCE, US, vol. 1, no. 4, 1 July 2009 (2009-07-01), pages 339 - 347, XP002657321, ISSN: 1942-0862
DAVIES J ET AL: "Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding", IMMUNOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 2, no. 3, 1 September 1996 (1996-09-01), pages 169 - 179, XP004070292, ISSN: 1380-2933, DOI: 10.1016/S1380-2933(96)00045-0
WU CHENGBIN ET AL: "Molecular construction and optimization of anti-human IL-1 alpha/beta dual variable domain immunoglobulin (DVD-Ig (TM)) molecules", MABS, LANDES BIOSCIENCE, US, vol. 1, no. 4, 1 July 2009 (2009-07-01), pages 339 - 347, XP002657321, ISSN: 1942-0862
Attorney, Agent or Firm:
VELEMA, James H. et al. (28 State Street Suite 070, Boston MA, US)
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