Title:
IL-18 VARIANT POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2024/051728
Kind Code:
A1
Abstract:
Provided are interleukin 18 (IL-18) variant polypeptides that comprise mutation (s) at one or more of G3, E6, D54, and N91, wherein amino acid positions are relative to a wild-type human IL-18 set forth in SEQ ID NO: 1. Also provided are IL-18 variant polypeptide comprising (such as further comprising) at least one mutation at a residue selected from the group consisting of: C38, C68, C76, D98, S117, and C127, wherein the amino acid position is relative to a wild-type human IL-18 set forth in SEQ ID NO: 1. Also provided are IL-18 variant polypeptides bind IL-18Rα and exhibit substantially reduced binding to IL-18BP relative to the wild-type IL-18. Also provided are IL-18 variant polypeptides that exhibit increased binding IL-18Rα relative to the wild-type IL-18 and substantially reduced binding to IL-18BP relative to the wild-type IL-18. Also provided are related nucleic acids, vectors, host cells, methods of producing IL-18 variant polypeptides, pharmaceutical compositions comprising IL-18 variant polypeptides, and uses of such pharmaceutical compositions.
Inventors:
QIANG MIN (CN)
CHEN XI (CN)
WANG ZHENGYI (CN)
ZENG HUI (CN)
ZHENG XIN (CN)
ZHANG FEI (CN)
YUAN PUWEI (CN)
LIU FAN (CN)
CHEN XI (CN)
WANG ZHENGYI (CN)
ZENG HUI (CN)
ZHENG XIN (CN)
ZHANG FEI (CN)
YUAN PUWEI (CN)
LIU FAN (CN)
Application Number:
PCT/CN2023/117197
Publication Date:
March 14, 2024
Filing Date:
September 06, 2023
Export Citation:
Assignee:
I MAB BIOPHARMA CO LTD (CN)
International Classes:
C07K14/715; A61K38/00; A61P35/00; C07K14/54
Domestic Patent References:
| WO2022094473A1 | 2022-05-05 | |||
| WO2021097376A1 | 2021-05-20 | |||
| WO2023161853A1 | 2023-08-31 |
Foreign References:
| US20190070262A1 | 2019-03-07 | |||
| CN111315395A | 2020-06-19 | |||
| US20050008615A1 | 2005-01-13 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
Download PDF:
Previous Patent: PYRAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION, AND USE
Next Patent: TRANSLITERATION METHOD AND ELECTRONIC DEVICE
Next Patent: TRANSLITERATION METHOD AND ELECTRONIC DEVICE