Title:
IMAGING AGENT FOR DETECTION OF SENTINEL LYMPH NODE COMPRISING THERMORESPONSIVE MAGNETIC NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2008/111687
Kind Code:
A1
Abstract:
Disclosed is an MRI imaging agent for use in the specific detection of a sentinel lymph node, which comprises a thermoresponsive magnetic nanoparticle. Specifically disclosed is a imaging agent for a sentinel lymph node, which comprises a thermoresponsive magnetic nanoparticle having an average particle diameter of 70 to 100 nm, wherein the thermoresponsive magnetic nanoparticle comprises a magnetic particle coated with a thermoresponsive polymer having an upper critical solution temperature and/or a lower critical solution temperature. The imaging agent can accumulate in a sentinel lymph node at high density.
Inventors:
UEDA MASAKAZU (JP)
Application Number:
PCT/JP2008/055177
Publication Date:
September 18, 2008
Filing Date:
March 14, 2008
Export Citation:
Assignee:
UNIV KEIO (JP)
UEDA MASAKAZU (JP)
UEDA MASAKAZU (JP)
International Classes:
A61K49/00; A61B5/055; A61K9/51; A61K47/32
Other References:
HIRAIWA K. ET AL.: "OPTIMIZATION OF SENTINEL LYMPH NODES WITH INTERSTITIAL MAGNETIC NANOPARTICLES IN RATS", PROC. ANNU. MEET. AM. ASSOC. CANCER RES., vol. 48, April 2007 (2007-04-01), pages 1122
KONDO A. AND ONISHI N.: "Dai 2 Sho Mirai Gijutsu no Tameno Funtai Nano Technology 2.3 Bio Gijutsu no Tameno Funtai Nano Technology 2.3.3 Jisei Nano Fukugo Ryushi no Gosei to Bio Technology eno Oyo", JOURNAL OF THE SOCIETY OF POWDER TECHNOLOGY, JAPAN, vol. 43, no. 12, 10 December 2006 (2006-12-10), pages 906 - 911
OHNISHI N. ET AL.: "HIGH-EFFICIENCY BIOAFFINITY SEPARATION OF CELLS AND PROTEINS USING NOVEL THERMORESPONSIVE BIOTINYLATED MAGNETIC NANOPARTICLES", NANOBIOTECHNOLOGY, vol. 2, 2006, pages 43 - 49, XP009182208
KONDO A. AND ONISHI N.: "Dai 2 Sho Mirai Gijutsu no Tameno Funtai Nano Technology 2.3 Bio Gijutsu no Tameno Funtai Nano Technology 2.3.3 Jisei Nano Fukugo Ryushi no Gosei to Bio Technology eno Oyo", JOURNAL OF THE SOCIETY OF POWDER TECHNOLOGY, JAPAN, vol. 43, no. 12, 10 December 2006 (2006-12-10), pages 906 - 911
OHNISHI N. ET AL.: "HIGH-EFFICIENCY BIOAFFINITY SEPARATION OF CELLS AND PROTEINS USING NOVEL THERMORESPONSIVE BIOTINYLATED MAGNETIC NANOPARTICLES", NANOBIOTECHNOLOGY, vol. 2, 2006, pages 43 - 49, XP009182208
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chome,Minato-k, Tokyo 01, JP)
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