Title:
IMAGING MASS SPECTROMETER AND IMAGING MASS SPECTROMETRY DATA PROCESSING METHOD
Document Type and Number:
WIPO Patent Application WO/2022/003890
Kind Code:
A1
Abstract:
An aspect of an imaging mass spectrometer according to the present invention comprises: a measurement unit (3) which performs LC/MS analysis for individual samples that have been respectively collected from a plurality of micro regions set in a measurement region on a sample and which acquires, for each sample, three-dimensional data having dimensions that are a retention time, m/z, and a signal strength; a heat map creation unit (42, 43) which integrates or averages signal strengths for each combination of the retention time and m/z to obtain a representative signal strength value on the basis of three dimensional data that has been acquired by the measurement unit for the plurality of micro regions included in the whole or a part of the measurement region and which creates a heat map that indicates the representative signal strength value by a shade or color, with the retention time and m/z as respective axes; an instruction reception unit (46) which displays the heat map on a display screen and enables a user to designate a specific position or range on the heat map; and an image creation unit (44) which identifies a retention time and m/z corresponding to the designated position or range and which extracts pieces of data corresponding to the retention time and m/z from the three dimensional data to create an image indicating a two dimensional distribution of signal strengths.
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Inventors:
KOGA YUSUKE (JP)
OGAWA KIYOSHI (JP)
MATSUMOTO RYUTA (JP)
OGAWA KIYOSHI (JP)
MATSUMOTO RYUTA (JP)
Application Number:
PCT/JP2020/025957
Publication Date:
January 06, 2022
Filing Date:
July 02, 2020
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2018034346A1 | 2018-02-22 | |||
| WO2016163385A1 | 2016-10-13 | |||
| WO2015053039A1 | 2015-04-16 |
Foreign References:
| JP2015049055A | 2015-03-16 | |||
| JP2009539067A | 2009-11-12 | |||
| JP2007527992A | 2007-10-04 | |||
| JP2009053070A | 2009-03-12 | |||
| JP2015114327A | 2015-06-22 | |||
| US20170343529A1 | 2017-11-30 | |||
| US20160313334A1 | 2016-10-27 |
Other References:
GUSTAFSSON OVE J.R., JAMES S EDDES, STEPHAN MEDING, SHAUN R MCCOLL, MARTIN K OEHLER, PETER HOFFMANN: "Matrix-assisted laser desorption/ionization imaging protocol for in situ characterization of tryptic peptide identity and distribution in formalin-fixed tissue", RAPID COMMUN MASS SPECTROM ., vol. 27, no. 6, 30 March 2013 (2013-03-30), pages 655 - 670, XP055897582, DOI: 10.1002/rcm.6488
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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