Title:
IMIDAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2000/056718
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) or pharmacologically acceptable salts thereof, wherein Y represents hydrogen, cyano or carbamoyl; Z represents CH or nitrogen; -A-B- represents -CH¿2?-CH¿2?- or -CH=CH-; m is 1 or 2; and n is 0 or 1. Because of having an extremely potent and selective antagonism to muscarine M¿3? receptor, these compounds are useful as preventives or remedies for diseases in which muscarine M¿3? receptor participates. In addition, these compounds can provide safe drugs scarcely causing thirst which is a side effect of muscarine M¿3? receptor antagonists.
Inventors:
YASUDA NOBUYUKI (JP)
ENDOH JUN-ICHI (JP)
MIURA MASATAKA (JP)
AIZAWA HIDEYUKI (JP)
OHNO NORIO (JP)
ENDOH JUN-ICHI (JP)
MIURA MASATAKA (JP)
AIZAWA HIDEYUKI (JP)
OHNO NORIO (JP)
Application Number:
PCT/JP2000/001738
Publication Date:
September 28, 2000
Filing Date:
March 22, 2000
Export Citation:
Assignee:
MITSUBISHI TOKYO PHARM INC (JP)
YASUDA NOBUYUKI (JP)
ENDOH JUN ICHI (JP)
MIURA MASATAKA (JP)
AIZAWA HIDEYUKI (JP)
OHNO NORIO (JP)
YASUDA NOBUYUKI (JP)
ENDOH JUN ICHI (JP)
MIURA MASATAKA (JP)
AIZAWA HIDEYUKI (JP)
OHNO NORIO (JP)
International Classes:
C07D233/06; A61K31/00; A61K31/415; A61K31/4164; A61P1/00; A61P1/08; A61P11/00; A61P11/06; A61P13/00; A61P25/00; A61P43/00; C07D233/58; C07D521/00; (IPC1-7): C07D233/06; A61K31/4164; A61K31/4178; A61K31/454; C07D233/61; C07D401/06; C07D403/06
Domestic Patent References:
| WO1999014200A1 | 1999-03-25 |
Foreign References:
| EP0733621A1 | 1996-09-25 | |||
| JPH07291936A | 1995-11-07 |
Other References:
MIYACHI H. ET AL.: "Novel imidazole derivatives with subtype-selective antimuscarinic activity (2)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 16, 1998, pages 2163 - 2168, XP002933244
MIYACHI H. ET AL.: "Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 14, 1998, pages 1807 - 1812, XP002933245
MIYACHI H. ET AL.: "Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 14, 1998, pages 1807 - 1812, XP002933245
Attorney, Agent or Firm:
Matsuyama, Naoyuki (Inc. 2-6 Nihonbashi-honcho 2-chome Chuo-ku, Tokyo, JP)
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