Title:
IMIDAZOLIDINONE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/088839
Kind Code:
A1
Abstract:
An imidazolidinone compound represented by formula (I), or a stereoisomer thereof, a geometric isomer thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, a synthesis method therefor, and use thereof.
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Inventors:
ZU HOUXIAN (CN)
SONG XIZHEN (CN)
CHEN KAI (CN)
LIU XIANGYONG (CN)
CHEN JIE (CN)
BIAN YAJING (CN)
DING LIEMING (CN)
WANG JIABING (CN)
SONG XIZHEN (CN)
CHEN KAI (CN)
LIU XIANGYONG (CN)
CHEN JIE (CN)
BIAN YAJING (CN)
DING LIEMING (CN)
WANG JIABING (CN)
Application Number:
PCT/CN2020/126359
Publication Date:
May 14, 2021
Filing Date:
November 04, 2020
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/4162; C07D498/04; A61K31/4188; A61K31/4196; A61P35/00; C07D498/14; C07D519/00
Domestic Patent References:
| WO2017001658A1 | 2017-01-05 |
Foreign References:
| CN102762576A | 2012-10-31 | |||
| CN103562210A | 2014-02-05 | |||
| CN107995911A | 2018-05-04 |
Other References:
MA KCHEUNG SMMARSHALL AJ, CELL SIGNAL, vol. 20, 2008, pages 684 - 694
VANHAESEBROECK BWATERFIELD MD, EXP CELL RES, vol. 253, 1999, pages 239 - 254
WU PLIU THU Y, CURR MED CHEM, vol. 16, 2009, pages 916 - 930
FALASCA MT. MUFFUCCI, BIOCHEM SOC TRANS, vol. 35, 2007, pages 211 - 214
SCHU PTAKEGAWA. KFRY. M, SCIENCE, vol. 260, 1993, pages 88 - 91
KONG DYAMORI T, CANCER SCI, vol. 99, 2008, pages 1734 - 1740
STEELMAN. LSCHAPPELL. WHABRAMS. SL ET AL., AGING, vol. 3, 2011, pages 192 - 222
DEJAN JURIC, CANCER RES, vol. 72, 2012, pages 1
"Design of Prodrugs", 1985, ELSEVIER
KOLA ILANDIS J, NAT REV DRUG DISCOV., vol. 3, no. 8, August 2004 (2004-08-01), pages 711 - 5
See also references of EP 4056575A4
VANHAESEBROECK BWATERFIELD MD, EXP CELL RES, vol. 253, 1999, pages 239 - 254
WU PLIU THU Y, CURR MED CHEM, vol. 16, 2009, pages 916 - 930
FALASCA MT. MUFFUCCI, BIOCHEM SOC TRANS, vol. 35, 2007, pages 211 - 214
SCHU PTAKEGAWA. KFRY. M, SCIENCE, vol. 260, 1993, pages 88 - 91
KONG DYAMORI T, CANCER SCI, vol. 99, 2008, pages 1734 - 1740
STEELMAN. LSCHAPPELL. WHABRAMS. SL ET AL., AGING, vol. 3, 2011, pages 192 - 222
DEJAN JURIC, CANCER RES, vol. 72, 2012, pages 1
"Design of Prodrugs", 1985, ELSEVIER
KOLA ILANDIS J, NAT REV DRUG DISCOV., vol. 3, no. 8, August 2004 (2004-08-01), pages 711 - 5
See also references of EP 4056575A4
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