Title:
IMIDAZOLIDINYL VANILLIC ACID ETHER DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/240378
Kind Code:
A1
Abstract:
Provided are an imidazolidinyl vanillic acid ether derivative shown in formula (I) and a use thereof. Compared with the prior art, the imidazolidinyl vanillic acid ether derivative shown in formula (I) has higher in-vivo bioavailability and in-vivo platelet aggregation inhibition activity, and can be used for treating and/or preventing diseases related to thromboembolism.
Inventors:
HE GUANGWEI (CN)
CHU ZHAOXING (CN)
XU QINLONG (CN)
LIN GAOFENG (CN)
MO JIAJIA (CN)
ZHAO YAN (CN)
CHU ZHAOXING (CN)
XU QINLONG (CN)
LIN GAOFENG (CN)
MO JIAJIA (CN)
ZHAO YAN (CN)
Application Number:
PCT/CN2022/098306
Publication Date:
December 21, 2023
Filing Date:
June 13, 2022
Export Citation:
Assignee:
NANJING INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
HEFEI INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
HEFEI AMVITE PHARMACEUTICAL CO LTD (CN)
HEFEI INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
HEFEI AMVITE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D233/60; A61K31/4164; A61P7/02; A61P7/10
Foreign References:
| US4602016A | 1986-07-22 | |||
| CN101851209A | 2010-10-06 |
Other References:
ZHOU PENG, HE YONG, LI JIAMING, XU QINLONG, SHENG RIZHENG: "Synthesis of Imidazole-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 28, no. 5, 31 May 2011 (2011-05-31), CN , pages 446 - 450, XP009551336, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2011.05.025
N.ACKERLEY ET AL.: "A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-Thromboxane receptor antagonists and- thromboxane synthase inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, 1 January 1995 (1995-01-01), US , pages 1608 - 1628, XP002450969, ISSN: 0022-2623, DOI: 10.1021/jm00010a005
ZHANG ENLI, ZHOU PENG, LI JIAMING, HE YONG, YUAN MING, XU QINLONG: "Synthesis of 4-[2-hydroxy-3-(1H-imidazolyl-1)propoxy]-3-methoxybenzoic acid and its analogues", SHANGHAI HUAGONG - SHANGHAI CHEMICAL INDUSTRY, SHANGHAI, CN, vol. 37, no. 9, 30 September 2012 (2012-09-30), CN , pages 14 - 16, XP009551337, ISSN: 1004-017X, DOI: 10.16759/j.cnki.issn.1004-017x.2012.09.012
N.ACKERLEY ET AL.: "A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-Thromboxane receptor antagonists and- thromboxane synthase inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 38, 1 January 1995 (1995-01-01), US , pages 1608 - 1628, XP002450969, ISSN: 0022-2623, DOI: 10.1021/jm00010a005
ZHANG ENLI, ZHOU PENG, LI JIAMING, HE YONG, YUAN MING, XU QINLONG: "Synthesis of 4-[2-hydroxy-3-(1H-imidazolyl-1)propoxy]-3-methoxybenzoic acid and its analogues", SHANGHAI HUAGONG - SHANGHAI CHEMICAL INDUSTRY, SHANGHAI, CN, vol. 37, no. 9, 30 September 2012 (2012-09-30), CN , pages 14 - 16, XP009551337, ISSN: 1004-017X, DOI: 10.16759/j.cnki.issn.1004-017x.2012.09.012
Attorney, Agent or Firm:
HAIWEN & PARTNERS (CN)
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