IMIDAZOLYLALKYLAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

WIPO Patent Application WO/1995/004723

A1

An imidazolylalkylamine derivative represented by general formula (I) useful as a steroid 17-20 lyase, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein R1 represents hydrogen or lower alkyl; A1 represents optionally branched lower alkylene; A2 represents optionally bonded or branched lower alkylene; R2 represents (un)substituted phenyl, (un)substituted bi- or tricyclic hydrocarbon ring having fused benzene ring(s); or (un)substituted bi- or tricyclic fused hetero ring having fused benzene ring(s) and a hetero ring containing oxygen and/or sulfur and/or nitrogen as the hetero atom(s); R3 represents alkyl, lower alkenyl, lower alkynyl, cycloalkyl, -A3-R4, halogen-substituted lower alkyl, cyano-substituted lower alkyl, or (un)substituted hetero ring containing nitrogen as the hetero atom(s); A3 represents optionally branched lower alkylene or carbonyl; and R4 represents (un)substituted cycloalkyl, (un)substituted phenyl, or (un)substituted hetero ring containing nitrogen as the hetero atom(s); provided (1) -A2-R2 and -R3 may be combined with the adjacent nitrogen atom to form (un)substituted tri- or tetracyclic fused hetero ring, and (2) when -A2-R2 represent (un)substituted phenyl or benzyl, (a) is bonded to the 4- or 5- position of the imidazole ring.

OKADA MINORU (JP)
YODEN TORU (JP)
KAWAMINAMI EIJI (JP)
SHIMADA YOSHIAKI (JP)
ISHIHARA TSUKASA (JP)
KUDOU MASAFUMI (JP)

PCT/JP1994/001278

February 16, 1995

August 03, 1994

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YAMANOUCHI PHARMA CO LTD (JP)
OKADA MINORU (JP)
YODEN TORU (JP)
KAWAMINAMI EIJI (JP)
SHIMADA YOSHIAKI (JP)
ISHIHARA TSUKASA (JP)
KUDOU MASAFUMI (JP)

C07D233/54; C07D233/64; C07D401/06; C07D403/06; C07D405/06; C07D409/06; C07D413/06; C07D417/06; C07D417/10; C07D513/04; C07D521/00; (IPC1-7): C07D233/64; A61K31/415; A61K31/425; A61K31/44; A61K31/495; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D513/04

JPS63141969A	1988-06-14
JPS5545684A	1980-03-31
GB1341375A	1973-12-19
JPH0386876A	1991-04-11
JPH02180885A	1990-07-13
JPH01151578A	1989-06-14
JPS6483065A	1989-03-28
JPS6485975A	1989-03-30
JPS58105970A	1983-06-24

J. MED. CHEM., Vol. 33, No. 6, 1990, pages 1688-1697.

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