IMIDAZOOXAZOLE DERIVATIVE HAVING ANTITUMOR EFFECT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

Title:

IMIDAZOOXAZOLE DERIVATIVE HAVING ANTITUMOR EFFECT, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

Document Type and Number:

WIPO Patent Application WO/2018/008920

Kind Code:

A1

Abstract:

Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.

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Inventors:

MAHMOUD GAMAL EL-DIN (EG)
CHOI HONG SEOK (KR)
YOO KYUNG HO (KR)
HAN DONG KEUN (KR)
OH CHANG HYUN (KR)
MOHAMMED ABDEL-MAKSOUD (EG)
MOHAMMED I EL-GAMAL (EG)

Application Number:

PCT/KR2017/007021

Publication Date:

January 11, 2018

Filing Date:

July 03, 2017

Export Citation:

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Assignee:

KOREA INST SCI & TECH (KR)

International Classes:

C07D498/04; A61K31/424; A61K31/429; A61K31/433; A61K31/506; C07D417/14; C07D513/04

Foreign References:

US20080161341A1	2008-07-03
US20150203498A1	2015-07-23
KR20110100241A	2011-09-09
KR20090090383A	2009-08-25

Other References:

ABDEL-MAKSOUD, M. S. ET AL.: "Design, Synthesis, in Vitro Antiproliferative Evaluation, and Kinase Inhibitory Effects of a New Series of Imidazo [2,1-b]thiazole Derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 95, 2015, pages 453 - 463, XP055569902
MARAIS; MARSHALL, CANCER SURV., vol. 27, 1996, pages 101 - 125
DAVIES, H. ET AL., NATURE, vol. 417, 2002, pages 949 - 954
TUVESON ET AL., CANCER CELL, vol. 4, 2003, pages 95 - 98
XING, ENDOCRINE-RELATED CANCER, vol. 12, 2005, pages 245 - 262
RAJAGOPALAN ET AL., NATURE, vol. 418, 2002, pages 934
SHARMA ET AL., CANFER RES., vol. 65, 2005, pages 2412 - 2421
WELLBROCK ET AL., CANCER RES., vol. 64, 2004, pages 2338 - 2342
HOEFLICH ET AL., CANCER RES., vol. 66, 2006, pages 999 - 1006
M.S. ABDEL-MAKSOUD ET AL., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 95, 2015, pages 453 - 463

Attorney, Agent or Firm:

Y.P.LEE, MOCK & PARTNERS (KR)

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