Title:
IMIDAZOPYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/077816
Kind Code:
A1
Abstract:
The invention relates to a novel imidazo[4,5-b]pyridine derivative compound represented by the formula (I) and a pharmaceutically acceptable salt thereof. The invention also relates to a method of producing the compound. The invention further relates to a pharmaceutical composition comprising the compound. The compound has a growth inhibiting activity against a cancer cell, and further, the activity is distinct from a growth inhibiting activity against a normal cell. Therefore, it is useful as a novel anticancer agent.
Inventors:
HIRAO ICHIRO (JP)
YOKOYAMA SHIGEYUKI (JP)
YOKOYAMA SHIGEYUKI (JP)
Application Number:
PCT/JP2006/300502
Publication Date:
July 27, 2006
Filing Date:
January 17, 2006
Export Citation:
Assignee:
RIKEN (JP)
HIRAO ICHIRO (JP)
YOKOYAMA SHIGEYUKI (JP)
HIRAO ICHIRO (JP)
YOKOYAMA SHIGEYUKI (JP)
International Classes:
A61K31/706; C07H19/052; A61P35/00
Domestic Patent References:
| WO2003093290A2 | 2003-11-13 |
Foreign References:
| JP2005232079A | 2005-09-02 | |||
| JPH0656877A | 1994-03-01 | |||
| JPH01283285A | 1989-11-14 |
Other References:
HOCEK M. ET AL.: "CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES III. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDY IN CYTOSTATIC ACTIVITY OF 6-ARYL-, 6-HETARYL- AND 6-BEZYLPURINE RIBONUCLEOSIDES", COLLECT. CZECH. CHEM. COMMUN., vol. 66, 2001, pages 483 - 499, XP002997963
CRISTALLI G. ET AL.: "SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-SUBSTITUTED PURINE AND DEAZAPURINE NUCLEOSIDES", NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 253 - 257, XP009046192
CRISTALLI G. ET AL.: "Purine and 1-Deazapurine Ribonucleosides and Deoxyribonucleosides: Synthesis and Biological Activity", J. MED. CHEM., vol. 34, 1991, pages 2226 - 2230, XP002323978
CRISTALLI G. ET AL.: "Improved Synthesis and Antitumor Activity of 1-Deazaadenosine", J. MED. CHEM., vol. 30, 1987, pages 1686 - 1688, XP002997964
BERGMAN A.M. ET AL.: "BIOLOGICAL ACTIVITY OF 1-DEAZAPURINE NUCLEOSIDES: ROLE OF DEOXYCYTIDINE KINASE?", NUCLEOSIDES & NUCLEOTIDES, vol. 18, no. 4 & 5, 1999, pages 897 - 898, XP002997965
G. CRISTALLI ET AL., NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 253 - 257
J. MED. CHEM., vol. 34, 1991, pages 2226 - 2230
See also references of EP 1847546A4
CRISTALLI G. ET AL.: "SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-SUBSTITUTED PURINE AND DEAZAPURINE NUCLEOSIDES", NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 253 - 257, XP009046192
CRISTALLI G. ET AL.: "Purine and 1-Deazapurine Ribonucleosides and Deoxyribonucleosides: Synthesis and Biological Activity", J. MED. CHEM., vol. 34, 1991, pages 2226 - 2230, XP002323978
CRISTALLI G. ET AL.: "Improved Synthesis and Antitumor Activity of 1-Deazaadenosine", J. MED. CHEM., vol. 30, 1987, pages 1686 - 1688, XP002997964
BERGMAN A.M. ET AL.: "BIOLOGICAL ACTIVITY OF 1-DEAZAPURINE NUCLEOSIDES: ROLE OF DEOXYCYTIDINE KINASE?", NUCLEOSIDES & NUCLEOTIDES, vol. 18, no. 4 & 5, 1999, pages 897 - 898, XP002997965
G. CRISTALLI ET AL., NUCLEOSIDES & NUCLEOTIDES, vol. 10, no. 1-3, 1991, pages 253 - 257
J. MED. CHEM., vol. 34, 1991, pages 2226 - 2230
See also references of EP 1847546A4
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
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