IMIDAZOTHIAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

WIPO Patent Application WO/2022/100727

A1

The present invention provides a novel class of imidazothiazole compounds as ATX (Autotaxin) inhibitors, a pharmaceutical composition comprising the compound, and a use of the compound and the composition to treat a mammal suffering from a disease having a pathological characteristic of increased ATX expression, wherein the compound has the structure represented by formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof, wherein R 1a, R 1c, R 2, R 3, R 6, Cy, Y, Z, and t all have the definitions described in the present invention.

ZOU QINGAN (CN)
ZHANG JIANCUN (CN)
CHEN YANWEI (CN)
ZHANG LIJUN (CN)
KANG NING (CN)
GUO CHEN (CN)

PCT/CN2021/130584

May 19, 2022

November 15, 2021

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GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN)

C07D513/04; A61K31/433; A61K31/438; A61K31/454; A61P3/00; A61P9/00; A61P35/00; C07D519/00

WO2014139882A1

2014-09-18

CN110526929A	2019-12-03
CN105339370A	2016-02-17
CN105143221A	2015-12-09
CN105814065A	2016-07-27

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THOMAS SORRELL: "Organic Chemistry", 1999
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19

GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)

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