Title:
IMMUNE RESPONSE REGULATORY SUBSTANCE AND VACCINE COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/080252
Kind Code:
A1
Abstract:
The present invention relates to an immune response regulatory substance having a novel structure, and an immunologic adjuvant composition containing the same and, more specifically, to an immune response regulatory substance, which is a lipopolysaccharide (LPS) analog having reduced toxicity, and a use thereof. The immune response regulatory substance of the present invention exhibits immune enhancement effects by having excellent innate immunity and ability to induce an adaptive immune response to a specific pathogen, and is very safe by having lox toxicity. In addition, a vaccine containing the immune response regulatory substance of the present invention contains both an immune response regulatory substance and an alum, thereby improving immune enhancement effects compared with when using only the immune response regulatory substance.
Inventors:
CHO YANG JE (KR)
KIM KWANGSUNG (KR)
LEE NA GYONG (KR)
PARK SHIN AE (KR)
KIM KWANGSUNG (KR)
LEE NA GYONG (KR)
PARK SHIN AE (KR)
Application Number:
PCT/KR2017/012050
Publication Date:
May 03, 2018
Filing Date:
October 30, 2017
Export Citation:
Assignee:
EYEGENE INC (KR)
International Classes:
A61K39/12; A61K39/00; A61K39/002; A61K39/295; A61K39/39
Foreign References:
| KR20120013260A | 2012-02-14 | |||
| KR20060117387A | 2006-11-17 | |||
| KR20030090897A | 2003-12-01 |
Other References:
BELLO, G. ET AL.: "The Influence of Rough Lipopolysaccharide Structure on Molecular Interactions with Mammalian Antimicrobial Peptides", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1858, 2016, pages 197 - 209, XP029374413
CLIFTON, L. A. ET AL.: "Asymmetric Phospholipid: Lipopolysaccharide Bilayers; a Gram-negative Bacterial Outer Membrane Mimic", JOURNAL OF THE ROYAL SOCIETY INTERFA, vol. 10, no. 89, 2013, pages 1 - 11, XP055481946
See also references of EP 3533463A4
CLIFTON, L. A. ET AL.: "Asymmetric Phospholipid: Lipopolysaccharide Bilayers; a Gram-negative Bacterial Outer Membrane Mimic", JOURNAL OF THE ROYAL SOCIETY INTERFA, vol. 10, no. 89, 2013, pages 1 - 11, XP055481946
See also references of EP 3533463A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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