Title:
IMMUNE STIMULATING OLIGONUCLEOTIDE AND USE THEREOF IN PHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2006/035939
Kind Code:
A1
Abstract:
A novel immune stimulating oligonucleotide having the activity of inducing strong immune responses; a pharmaceutical product comprising this immune stimulating oligonucleotide; and use thereof. This immune stimulating oligonucleotide, for example, consists of an oligonucleotide having the sequence of ggtgccgatcggcagggggg. This oligonucleotide can be used as an active ingredient of pharmaceuticals, such as a preventive or therapeutic agent for allergoses. As this immune stimulating oligonucleotide has a strong immune stimulating activity, the use thereof renders it promising to attain enhanced treating, preventive and remedial effects and to through reduction of administration frequency, attain side effect suppression and QOL remedy.
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Inventors:
NARUMI HIDEKI (JP)
KANEDA AKIHITO (JP)
FUKAO KAZUMASA (JP)
AKIRA SHIZUO (JP)
KANEDA AKIHITO (JP)
FUKAO KAZUMASA (JP)
AKIRA SHIZUO (JP)
Application Number:
PCT/JP2005/018148
Publication Date:
April 06, 2006
Filing Date:
September 30, 2005
Export Citation:
Assignee:
UNIV OSAKA (JP)
TORAY INDUSTRIES (JP)
NARUMI HIDEKI (JP)
KANEDA AKIHITO (JP)
FUKAO KAZUMASA (JP)
AKIRA SHIZUO (JP)
TORAY INDUSTRIES (JP)
NARUMI HIDEKI (JP)
KANEDA AKIHITO (JP)
FUKAO KAZUMASA (JP)
AKIRA SHIZUO (JP)
International Classes:
C07H21/02; A61K9/127; A61K31/7088; A61K31/7115; A61K31/712; A61K31/7125; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/02; A61P35/00; A61P37/02; A61P37/04; A61P37/08; C12N15/117
Domestic Patent References:
| WO2004058179A2 | 2004-07-15 |
Foreign References:
| JP2003510290A | 2003-03-18 | |||
| JP2002500159A | 2002-01-08 | |||
| JP2002517156A | 2002-06-11 | |||
| JP2001503267A | 2001-03-13 | |||
| JPH10506265A | 1998-06-23 | |||
| JPH04352724A | 1992-12-07 |
Other References:
MERIET JF ET AL: "Effect of oromucosal administration of IFN-alpha on allergic sensitization and the hypersensitive inflammatory response in animals sensitized to ragweed pollen.", J INTERFERON CYTOKINE RES., vol. 21, no. 8, 2001, pages 583 - 593, XP002994019
KIMURA Y ET AL: "Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN.", J BIOCHEM., vol. 116, no. 5, 1994, pages 991 - 994, XP000616565
VERTHELYI D ET AL: "Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.", J IMMUNOL., vol. 166, no. 4, 2001, pages 2372 - 2377, XP002299044
KIMURA Y ET AL: "Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN.", J BIOCHEM., vol. 116, no. 5, 1994, pages 991 - 994, XP000616565
VERTHELYI D ET AL: "Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.", J IMMUNOL., vol. 166, no. 4, 2001, pages 2372 - 2377, XP002299044
Attorney, Agent or Firm:
Tanigawa, Hidejiro c/o TANIGAWA AND ASSOCIATES (Patent Firm 6F, Iwata Bldg., 5-12, Iidabashi 4-chom, Chiyoda-ku Tokyo 72, JP)
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