Title:
IMMUNOASSAY FOR THRYOGLOBULIN AND KIT THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/013725
Kind Code:
A1
Abstract:
Provided is a novel method that can accurately measure the amount of thyroglobulin in a sample even for samples that are anti-thyroglobulin antibody positive. The immunoassay is a method that carries out an immunoassay-based measurement of the thyroglobulin in a sample isolated from an organism, wherein this method comprises a pretreatment step in which the sample isolated from the organism is treated with a reducing agent. The immunoassay uses a monoclonal antibody, or an antigen-binding fragment thereof, for which the corresponding antigen is reducing agent-treated thyroglobulin.
Inventors:
ARAI OSAMU (JP)
YAGI SHINTARO (JP)
AOYAGI KATSUMI (JP)
YAGI SHINTARO (JP)
AOYAGI KATSUMI (JP)
Application Number:
PCT/JP2022/029921
Publication Date:
February 09, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
ADVANCED LIFE SCIENCE INST INC (JP)
International Classes:
G01N33/53; C07K16/18; G01N33/531
Domestic Patent References:
| WO2018047792A1 | 2018-03-15 | |||
| WO2020241443A1 | 2020-12-03 | |||
| WO2021060450A1 | 2021-04-01 | |||
| WO2005111620A1 | 2005-11-24 | |||
| WO2018047792A1 | 2018-03-15 | |||
| WO2020241443A1 | 2020-12-03 |
Foreign References:
| JPH0746996A | 1995-02-21 | |||
| JPH0746966A | 1995-02-21 | |||
| US20150166678A1 | 2015-06-18 | |||
| US20150309016A1 | 2015-10-29 | |||
| US8039223B2 | 2011-10-18 | |||
| US20140186238A1 | 2014-07-03 | |||
| US7820398B2 | 2010-10-26 | |||
| US6210898B1 | 2001-04-03 |
Other References:
SUGAWA, H. ; SMITH, E. ; IMURA, H. ; MORI, T.: "A thyroid cancer specific monoclonal antibody which recognizes cryptic epitope(s) of human thyroglobulin", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 93, no. 2, 1 June 1993 (1993-06-01), IE , pages 207 - 211, XP025777677, ISSN: 0303-7207, DOI: 10.1016/0303-7207(93)90125-4
Y KISO , J FURMANIAK , C MORTERO , B REES SMITH: "Analysis of Carbohydrate Residues on Human Thyroid Peroxidase (Tpo) and Thyroglobulin (Tg) and Effects of Deglycosylation, Reduction and Unfolding on Autoantibody Binding", AUTOIMMUNITY, vol. 12, no. 4, 1 January 1992 (1992-01-01), GB , pages 259 - 269, XP009543267, ISSN: 0891-6934, DOI: 10.3109/08916939209148468
YOSHIYUKI KITAMURA : "Development of Lumipulse Presto iTACT Tg, an epoch-making reagent for measuring thyroglobulin that is not affected by autoantibodies", IGAKU TO YAKUGAKU [MEDICINE AND PHARMACY], vol. 77, no. 12, 27 November 2020 (2020-11-27), JP , pages 1683 - 1690, XP009543264, ISSN: 0389-3898
Y KISO , J FURMANIAK , C MORTERO , B REES SMITH: "Analysis of Carbohydrate Residues on Human Thyroid Peroxidase (Tpo) and Thyroglobulin (Tg) and Effects of Deglycosylation, Reduction and Unfolding on Autoantibody Binding", AUTOIMMUNITY, vol. 12, no. 4, 1 January 1992 (1992-01-01), GB , pages 259 - 269, XP009543267, ISSN: 0891-6934, DOI: 10.3109/08916939209148468
YOSHIYUKI KITAMURA : "Development of Lumipulse Presto iTACT Tg, an epoch-making reagent for measuring thyroglobulin that is not affected by autoantibodies", IGAKU TO YAKUGAKU [MEDICINE AND PHARMACY], vol. 77, no. 12, 27 November 2020 (2020-11-27), JP , pages 1683 - 1690, XP009543264, ISSN: 0389-3898
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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