IMMUNOCOMPATIBLE HUMAN PLURIPOTENT STEM CELL, METHOD FOR PREPARING SAME, AND USE THEREOF - SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES

Title:

IMMUNOCOMPATIBLE HUMAN PLURIPOTENT STEM CELL, METHOD FOR PREPARING SAME, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/002279

Kind Code:

A1

Abstract:

Provided are an immunocompatible human pluripotent stem cell, a method for preparing same, and use thereof. The modified human pluripotent stem cell can be induced and differentiated into various tissues/organ cells, has very ideal immunocompatibility, and has a wide application environment.

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Inventors:

YANG HUANG-TIAN (CN)
ZHANG PENG (CN)
RAO SEN-LE (CN)
ZHANG XIAOQING (CN)
LIU LING (CN)

Application Number:

PCT/CN2023/104109

Publication Date:

January 04, 2024

Filing Date:

June 29, 2023

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Assignee:

SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
SHANGHAI EAST HOSPITAL SCHOOL OF MEDICINE TONGJI UNIV (CN)
TONG JI UNIV (CN)

International Classes:

C12N5/10; C07K14/74; C07K19/00; C12N15/62; C12N15/867

Foreign References:

CN113528448A	2021-10-22
CN112342196A	2021-02-09
CN114107211A	2022-03-01
CN110177869A	2019-08-27

Other References:

WANG XIAOKAI, LU MENG, TIAN XIAOYU, REN YANSONG, LI YIJUN, XIANG MENG, CHEN SIFENG: "Diminished expression of major histocompatibility complex facilitates the use of human induced pluripotent stem cells in monkey", STEM CELL RESEARCH & THERAPY, BIOMED CENTRAL LTD, LONDON, UK, vol. 11, no. 1, 1 December 2020 (2020-12-01), London, UK , XP093121396, ISSN: 1757-6512, DOI: 10.1186/s13287-020-01847-9
ZHENG, D. J. ET AL.: "Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes", INT. J. BIOL. SCI., vol. 18, no. 1, 1 January 2022 (2022-01-01), pages 426 - 440, XP093069310, DOI: 10.7150/ijbs.64640

Attorney, Agent or Firm:

SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)

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