Title:
IMMUNOCYTE ACTIVATOR, AND THERAPEUTIC AGENT FOR IMMUNOCYTE-RELATED INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/233665
Kind Code:
A1
Abstract:
Provided are: an immunocyte activator containing, as an active ingredient, a substance which inhibits the binding of fibronectin and an immunosuppressive receptor LILRB4; and a therapeutic agent for immunocyte-related inflammatory diseases, the therapeutic agent containing, as an active ingredient, a substance which inhibits the binding of fibronectin and an immunosuppressive receptor LILRB4.
Inventors:
TAKAI TOSHIYUKI (JP)
SU MEI TZU (JP)
SU MEI TZU (JP)
Application Number:
PCT/JP2022/022682
Publication Date:
December 07, 2023
Filing Date:
June 03, 2022
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K45/00; A61K38/10; A61K38/39; A61K39/395; A61P9/10; A61P25/18; A61P25/28; A61P29/00; A61P43/00
Domestic Patent References:
| WO2021029318A1 | 2021-02-18 |
Other References:
SU MEI-TZU, INUI MASANORI, WONG YI LI, TAKAHASHI MAIKA, SUGAHARA-TOBINAI AKIKO, ONO KARIN, MIYAMOTO SHOTARO, MURAKAMI KEIICHI, ITO: "Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/ Yaa mice", DEPARTMENT OF EXPERIMENTAL IMMUNOLOGY, INSTITUTE OF DEVELOPMENT, AGING AND CANCER, TOHOKU UNIVERSITY , SENDAI 980-8575 , JAPAN, vol. 33, no. 8, 23 July 2021 (2021-07-23), pages 447 - 458, XP093063786, DOI: 10.1093/intimm/dxab028
ITOI SO, TAKAHASHI NAOYUKI, SAITO HARUKA, MIYATA YUSUKE, SU MEI-TZU, KEZUKA DAI, ITAGAKI FUMIKA, ENDO SHOTA, FUJII HIROSHI, HARIGA: "Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages", INTERNATIONAL IMMUNOLOGY JUN 2010, vol. 34, no. 8, 26 July 2022 (2022-07-26), pages 435 - 444, XP093116309, ISSN: 1460-2377, DOI: 10.1093/intimm/dxac023
TAKAHASHI NAOYUKI, ITOI SO, SU MEI-TZU, ENDO SHOTA, TAKAI TOSHIYUKI: "Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI., JP, vol. 257, no. 3, 1 January 2022 (2022-01-01), JP , pages 171 - 180, XP093116311, ISSN: 0040-8727, DOI: 10.1620/tjem.2022.J014
ITOI SO, TAKAHASHI NAOYUKI, SAITO HARUKA, MIYATA YUSUKE, SU MEI-TZU, KEZUKA DAI, ITAGAKI FUMIKA, ENDO SHOTA, FUJII HIROSHI, HARIGA: "Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages", INTERNATIONAL IMMUNOLOGY JUN 2010, vol. 34, no. 8, 26 July 2022 (2022-07-26), pages 435 - 444, XP093116309, ISSN: 1460-2377, DOI: 10.1093/intimm/dxac023
TAKAHASHI NAOYUKI, ITOI SO, SU MEI-TZU, ENDO SHOTA, TAKAI TOSHIYUKI: "Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE., TOHOKU UNIVERSITY MEDICAL PRESS, SENDAI., JP, vol. 257, no. 3, 1 January 2022 (2022-01-01), JP , pages 171 - 180, XP093116311, ISSN: 0040-8727, DOI: 10.1620/tjem.2022.J014
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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