Title:
IMMUNODOMINANT HUMAN T-CELL EPITOPES OF HEPATITIS C VIRUS
Document Type and Number:
WIPO Patent Application WO1995012677
Kind Code:
A3
Abstract:
The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the E2 region of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
Inventors:
LEROUX-ROELS GEERT (BE)
DELEYS ROBERT (BE)
MAERTENS GEERT (BE)
DELEYS ROBERT (BE)
MAERTENS GEERT (BE)
Application Number:
PCT/EP1994/003555
Publication Date:
July 27, 1995
Filing Date:
October 28, 1994
Export Citation:
Assignee:
INNOGENETICS NV (BE)
LEROUX ROELS GEERT (BE)
DELEYS ROBERT (BE)
MAERTENS GEERT (BE)
LEROUX ROELS GEERT (BE)
DELEYS ROBERT (BE)
MAERTENS GEERT (BE)
International Classes:
C12N15/09; A61K39/00; A61K39/29; A61P31/12; A61P31/14; A61P37/04; C07K14/18; C12N15/40; (IPC1-7): C12N15/40; A61K39/12; C07K14/18
Domestic Patent References:
| WO1992022571A1 | 1992-12-23 |
Other References:
LIN, H.J. ET AL.: "The hepatitis C virus genome: a guide to its conserved sequences and candidate epitopes", VIRUS RESEARCH, vol. 30, no. 1, October 1993 (1993-10-01), AMSTERDAM, NL, pages 27 - 41
ALVARADO ESQUIVEL, C.C. ET AL.: "T cell recognition of hepatitis C virus in patients with chronic hepatitis C", GASTROENTEROLOGY, vol. 104, no. 4PT2, April 1993 (1993-04-01), pages A660
KOZIEL, M. J. ET AL.: "Hepatitis C Virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV", JOURNAL OF VIROLOGY, vol. 67, no. 12, December 1993 (1993-12-01), pages 7522 - 7532
ALVARADO ESQUIVEL, C.C. ET AL.: "T cell recognition of hepatitis C virus in patients with chronic hepatitis C", GASTROENTEROLOGY, vol. 104, no. 4PT2, April 1993 (1993-04-01), pages A660
KOZIEL, M. J. ET AL.: "Hepatitis C Virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV", JOURNAL OF VIROLOGY, vol. 67, no. 12, December 1993 (1993-12-01), pages 7522 - 7532
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