Title:
IMMUNOGENIC PHARMACEUTICALS
Document Type and Number:
WIPO Patent Application WO1995032731
Kind Code:
A3
Abstract:
There are disclosed pharmaceuticals which comprise either part or all of a polypeptide or a nucleotide sequence coding for said part or all of a polypeptide which polypeptide is substantially homologous to a mutant protein produced in consequence of its mutation in a gene sequence which shifts translation from the gene sequence out of the list reading enzyme into either the second or third reading frames downstream of the mutation and which said part or all of a polypeptide is able to involve an immune response against the mutant protein.
Inventors:
TOWNSEND ALAIN ROBERT MICHAEL (GB)
Application Number:
PCT/GB1995/001274
Publication Date:
December 21, 1995
Filing Date:
June 01, 1995
Export Citation:
Assignee:
UNIV OXFORD (GB)
MEDICAL RES COUNCIL (GB)
TOWNSEND ALAIN ROBERT MICHAEL (GB)
MEDICAL RES COUNCIL (GB)
TOWNSEND ALAIN ROBERT MICHAEL (GB)
International Classes:
C12N15/09; A61K35/76; A61K39/00; A61K39/12; A61K48/00; A61P35/00; A61P37/00; C07K14/47; C12N5/10; C12N7/00; (IPC1-7): A61K39/00; A61K48/00; C12N15/12; C12N15/86; C12N5/10; A61K38/17
Domestic Patent References:
| WO1994010323A1 | 1994-05-11 |
Foreign References:
| US4687737A | 1987-08-18 | |||
| EP0565794A1 | 1993-10-20 |
Other References:
HARRIS C.C. ET AL.: "Clinical implications of the p53 tumor-suppressor gene", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 329, no. 18
YASUO MIYOSHI ET AL.: "Somatic mutations of the APC gene in colrectal tumors : mutation cluster region in the APC gene", HUMAN MOLECULAR GENETICS, vol. 1, no. 4, pages 229 - 233
ROY N: "Generation of influenza-specific cytotoxic T-lymphocytes by retroviral gene transfer.", DISS ABSTR INT [B];54(3):1242 1993
AKIRA HORII ET AL.: "The APC gene , responsible for familial adenomatous polyposis , is mutated in human gastric cancer", CANCER RESEARCH, vol. 52, pages 3231 - 3233
YASUO MIYOSHI ET AL.: "Somatic mutations of the APC gene in colrectal tumors : mutation cluster region in the APC gene", HUMAN MOLECULAR GENETICS, vol. 1, no. 4, pages 229 - 233
ROY N: "Generation of influenza-specific cytotoxic T-lymphocytes by retroviral gene transfer.", DISS ABSTR INT [B];54(3):1242 1993
AKIRA HORII ET AL.: "The APC gene , responsible for familial adenomatous polyposis , is mutated in human gastric cancer", CANCER RESEARCH, vol. 52, pages 3231 - 3233
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