Title:
IMMUNOGLOBULIN AFFINITY LIGAND
Document Type and Number:
WIPO Patent Application WO/2007/097361
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a carrier for immunoglobulin affinity chromatography that simultaneously has high immunoglobulin binding capability and chemical stability and that can be produced at low cost. [MEANS FOR SOLVING PROBLEMS] An immunoglobulin binding protein wherein an amino acid substitution for not only maximizing the number of lysine residues on the protein surface of helix 3 and its periphery but also minimizing the number of lysine residues present on the protein surface of helix 1 and helix 2 as immunoglobulin binding regions and/or an amino acid substitution for eliminating of asparagine acid-proline sequence has been carried out, or a multimer thereof, is used as an affinity ligand of carrier for affinity chromatography.
Inventors:
MAJIMA EIJI (JP)
SHIMA ATSUSHI (JP)
HARA YUKO (JP)
SHIMA ATSUSHI (JP)
HARA YUKO (JP)
Application Number:
PCT/JP2007/053189
Publication Date:
August 30, 2007
Filing Date:
February 21, 2007
Export Citation:
Assignee:
PROTENOVA CO LTD (JP)
MAJIMA EIJI (JP)
SHIMA ATSUSHI (JP)
HARA YUKO (JP)
MAJIMA EIJI (JP)
SHIMA ATSUSHI (JP)
HARA YUKO (JP)
International Classes:
C12N15/09; C07K1/22; C07K14/31; C07K17/00; C12M1/00; G01N30/88; G01N33/53; G01N37/00; C07K16/00
Domestic Patent References:
| WO2003080655A1 | 2003-10-02 |
Foreign References:
| JP2006304633A | 2006-11-09 | |||
| US6548639B1 | 2003-04-15 | |||
| US6399750B1 | 2002-06-04 | |||
| JP2000500649A | 2000-01-25 | |||
| JP2005112827A | 2005-04-28 | |||
| JP2005538693A | 2005-12-22 |
Other References:
JENDEBERG L. ET AL.: "Kinetic analysis of the interaction between protein A domain variants and human Fc using plasmon resonance detection", JOURNAL OF MOLECULAR RECOGNITION, vol. 8, no. 4, 1995, pages 270 - 278, XP009024185
SCARAMOZZINO F. ET AL.: "Improvement of catalytic properties of Escherichia coli penicillin G acylase immobilized on glyoxyl agarose by addition of a six-amino-acid tag", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 71, no. 12, 2005, pages 8937 - 8940, XP003016589
LADAVIERE C. ET AL.: "Covalent immobilization of proteins onto (Maleic anhydride-alt-methyl vinyl ether) copolymers: enhanced immobilization of recombinant proteins", BIOCONJUGATE CHEMISTRY, vol. 9, no. 6, 1998, pages 655 - 661, XP003016590
ALLARD L. ET AL.: "Mechanisms leading to an oriented immobilization of recombinant proteins derived from the P24 capsid of HIV-1 onto copolymers", BIOCONJUGATE CHEMISTRY, vol. 12, no. 6, 2001, pages 972 - 979, XP003016591
ALLARD L. ET AL.: "Versatile method for production and controlled polymer-immobilization of biologically active recombinant proteins", BIOTECHNOLOGY AND BIOENGINEERING, vol. 80, no. 3, 2002, pages 341 - 348, XP002431786
TASHIRO M. ET AL.: "High-resolution solution NMR structure of the Z domain of staphyloccocal protein A", JOURNAL OF MOLECULAR BIOLOGY, vol. 272, no. 4, 1997, pages 573 - 590, XP004453779
NILSSON B ET AL., PROTEIN ENGINEERING, vol. 1, no. 2, 1987, pages 107 - 113
TASHIRO M. ET AL.: "High-resolution solution NMR structure of the Z domain of staphyrococcal proteinA", JOURNAL OF MOLECULAR BIOLOGYVOL., vol. 272, no. 4, 1997, pages 573 - 590
MELISSA A. ET AL.: "Structural mimicry of a native protein by a minimized binding domain", PROCEEDING NATURAL ACADEMY OF SCIENCES USA, vol. 94, 1997, pages 10
JANSSON, J.C.; RYDEN, L.: "Protein purification", pages: 375 - 442
See also references of EP 1992692A4
SCARAMOZZINO F. ET AL.: "Improvement of catalytic properties of Escherichia coli penicillin G acylase immobilized on glyoxyl agarose by addition of a six-amino-acid tag", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 71, no. 12, 2005, pages 8937 - 8940, XP003016589
LADAVIERE C. ET AL.: "Covalent immobilization of proteins onto (Maleic anhydride-alt-methyl vinyl ether) copolymers: enhanced immobilization of recombinant proteins", BIOCONJUGATE CHEMISTRY, vol. 9, no. 6, 1998, pages 655 - 661, XP003016590
ALLARD L. ET AL.: "Mechanisms leading to an oriented immobilization of recombinant proteins derived from the P24 capsid of HIV-1 onto copolymers", BIOCONJUGATE CHEMISTRY, vol. 12, no. 6, 2001, pages 972 - 979, XP003016591
ALLARD L. ET AL.: "Versatile method for production and controlled polymer-immobilization of biologically active recombinant proteins", BIOTECHNOLOGY AND BIOENGINEERING, vol. 80, no. 3, 2002, pages 341 - 348, XP002431786
TASHIRO M. ET AL.: "High-resolution solution NMR structure of the Z domain of staphyloccocal protein A", JOURNAL OF MOLECULAR BIOLOGY, vol. 272, no. 4, 1997, pages 573 - 590, XP004453779
NILSSON B ET AL., PROTEIN ENGINEERING, vol. 1, no. 2, 1987, pages 107 - 113
TASHIRO M. ET AL.: "High-resolution solution NMR structure of the Z domain of staphyrococcal proteinA", JOURNAL OF MOLECULAR BIOLOGYVOL., vol. 272, no. 4, 1997, pages 573 - 590
MELISSA A. ET AL.: "Structural mimicry of a native protein by a minimized binding domain", PROCEEDING NATURAL ACADEMY OF SCIENCES USA, vol. 94, 1997, pages 10
JANSSON, J.C.; RYDEN, L.: "Protein purification", pages: 375 - 442
See also references of EP 1992692A4
Attorney, Agent or Firm:
SUDO, Asako et al. (Kajino-Cho Koganei-Shi, Tokyo 02, JP)
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