Title:
IMMUNOGLOBULIN E VACCINES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003015716
Kind Code:
A3
Abstract:
The present invention concerns the prophylaxis or therapy of immunoglobulin E-mediated disease conditions. The present invention discloses methods for identifying peptides that induce a cytotoxic T-lymphocyte response against immunoglobulin E. The present invention further discloses compositions that are able to elicit in a mammal a cytotoxic T-lymphocyte response to naturally processed and presented immunoglobulin E peptides, and methods for their use.
Inventors:
CHEN SWEY-SHEN ALEX (US)
YANG YONG-MIN (US)
BARANKIEWICZ THERESA (US)
CHEN ZHONG (US)
YANG YONG-MIN (US)
BARANKIEWICZ THERESA (US)
CHEN ZHONG (US)
Application Number:
PCT/US2002/026986
Publication Date:
November 04, 2004
Filing Date:
August 08, 2002
Export Citation:
Assignee:
CHEN SWEY-SHEN ALEX (US)
YANG YONG-MIN (US)
BARANKIEWICZ THERESA (US)
CHEN ZHONG (US)
IGE THERAPEUTICS INC (US)
YANG YONG-MIN (US)
BARANKIEWICZ THERESA (US)
CHEN ZHONG (US)
IGE THERAPEUTICS INC (US)
International Classes:
A61K38/17; A61P11/06; A61P37/08; C07K16/00; C07K16/44; G01N33/50; G01N33/569; G01N33/68; (IPC1-7): G01N33/567; C12N5/06; A61K39/38
Other References:
JIN X. ET AL: "Identification of Subdominant Cytotoxic T Lymphocyte Epitopes Encoded by Autologous HIV Type 1 Sequences, Using Dendritic Cell Stimulation and Computer-Driven Algorithm", AIDS RESEARCH HUMAN RETROVIRUSES, vol. 16, no. 1, 1 January 2000 (2000-01-01), pages 68 - 69, XP002219619
AVESKOGH M. ET AL: "Evidence for an early appearance of modern post-switch isotypes in mammalian evolution; cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, September 1998 (1998-09-01), pages 2738 - 2750, XP002981052
PALIARD X. ET AL: "Induction of Herpes Simplex Virus gB-Specific Cytotoxic T Lymphocytes in TAP1-Deficient Mice by Genetic Immunization but Not HSV Infection", VIROLOGY, vol. 282, 30 March 2001 (2001-03-30), pages 56 - 64, XP002981053
MACARY P.A. ET AL: "Ovalbumin-Specific, MHC Class I-Restricted, ß-Positive, Tc1 and Tc0 CD8+ T Cell Clones Mediate the In Vivo Inhibition of Rat IgE", JOURNAL OF IMMUNOLOGY, vol. 160, 15 January 1998 (1998-01-15), pages 580 - 587, XP002981054
STEVENS J. ET AL: "Peptide length preferences for rat and mouse MHC class I molecules using random peptide libraries", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, April 1998 (1998-04-01), pages 1272 - 1279, XP002981055
AVESKOGH M. ET AL: "Evidence for an early appearance of modern post-switch isotypes in mammalian evolution; cloning of IgE, IgG and IgA from the marsupial Monodelphis domestica", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, September 1998 (1998-09-01), pages 2738 - 2750, XP002981052
PALIARD X. ET AL: "Induction of Herpes Simplex Virus gB-Specific Cytotoxic T Lymphocytes in TAP1-Deficient Mice by Genetic Immunization but Not HSV Infection", VIROLOGY, vol. 282, 30 March 2001 (2001-03-30), pages 56 - 64, XP002981053
MACARY P.A. ET AL: "Ovalbumin-Specific, MHC Class I-Restricted, ß-Positive, Tc1 and Tc0 CD8+ T Cell Clones Mediate the In Vivo Inhibition of Rat IgE", JOURNAL OF IMMUNOLOGY, vol. 160, 15 January 1998 (1998-01-15), pages 580 - 587, XP002981054
STEVENS J. ET AL: "Peptide length preferences for rat and mouse MHC class I molecules using random peptide libraries", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, April 1998 (1998-04-01), pages 1272 - 1279, XP002981055
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