Title:
IMMUNOMODULATING POLYMERS
Document Type and Number:
WIPO Patent Application WO2000059515
Kind Code:
A3
Abstract:
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
Inventors:
TZIANABOS ARTHUR O
KASPER DENNIS L
ONDERDONK ANDREW B
WANG YING
KASPER DENNIS L
ONDERDONK ANDREW B
WANG YING
Application Number:
PCT/US2000/008586
Publication Date:
January 11, 2001
Filing Date:
March 31, 2000
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
A61K31/192; A61K31/7088; A61K31/715; A61K31/785; A61K35/26; A61K35/74; A61K38/00; A61K38/16; A61K38/20; A61K39/395; A61K45/00; A61K45/06; A61P1/04; A61P3/10; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C12N5/07; C12N5/0783; (IPC1-7): A61K31/7088; A61K38/00; A61K38/20; A61K39/395; A61P37/02
Domestic Patent References:
| WO1996007427A1 | 1996-03-14 | |||
| WO1996032119A1 | 1996-10-17 |
Foreign References:
| DE3704389A1 | 1988-08-25 |
Other References:
V.K. PERUMAL ET AL.: "PROTECTIVE EFFECT OF INTERLEUKIN-2 ON EXPERIMENTAL INTRA-ABDOMINAL ABSCESS DEVELOPMENT DUE TO BACTEROIDES FRAGILIS.", CLINICAL RESEARCH, vol. 38, no. 2, 1990, NEW YORK, N.Y., US, pages 550A, XP000952900
A.O. TZIANABOS ET AL.: "STRUCTURAL CHARACTERISTICS OF POLYSACCHARIDES THAT INDUCE PROTECTION AGAINST INTR-ABDOMINAL ABSCESS FORMATION.", INFECTION AND IMMUNITY, vol. 62, no. 11, November 1994 (1994-11-01), WASHINGTON, US, pages 4881 - 4886, XP002150692
W.M. KALKA-MOLL ET AL.: "BACTEROIDES FRAGILIS NCTC 9343 CAPSULAR POLYSACCHARIDE PS A AND THE EFFECT OF CHAIN LENGHT ON T CELL PROLIFERATION.", ABSTRACTS OF THE 98 TH GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, ATLANTA, US, MAY 17-21, 1998, vol. 98, 1998, WASHINGTON, US, pages 123, XP002150693
A. TZIANABOS ET AL.: "T CELL ACTIVATION BY ZWITTERIONIC POLYSACCHARIDES AND PEPTIDE MIMETICS PREVENTS ANTRABDOMINAL ABSCESS FORMATION.", ABSTRACTS OF THE 99 TH GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, CHICAGO, US, MAY 30-JUNE 3, 1999, vol. 99, - 3 June 1999 (1999-06-03), WASHINGTON, US, pages 37 - 38, XP002150694
A.O. TZIANABOS ET AL.: "STRUCTURAL CHARACTERISTICS OF POLYSACCHARIDES THAT INDUCE PROTECTION AGAINST INTR-ABDOMINAL ABSCESS FORMATION.", INFECTION AND IMMUNITY, vol. 62, no. 11, November 1994 (1994-11-01), WASHINGTON, US, pages 4881 - 4886, XP002150692
W.M. KALKA-MOLL ET AL.: "BACTEROIDES FRAGILIS NCTC 9343 CAPSULAR POLYSACCHARIDE PS A AND THE EFFECT OF CHAIN LENGHT ON T CELL PROLIFERATION.", ABSTRACTS OF THE 98 TH GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, ATLANTA, US, MAY 17-21, 1998, vol. 98, 1998, WASHINGTON, US, pages 123, XP002150693
A. TZIANABOS ET AL.: "T CELL ACTIVATION BY ZWITTERIONIC POLYSACCHARIDES AND PEPTIDE MIMETICS PREVENTS ANTRABDOMINAL ABSCESS FORMATION.", ABSTRACTS OF THE 99 TH GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, CHICAGO, US, MAY 30-JUNE 3, 1999, vol. 99, - 3 June 1999 (1999-06-03), WASHINGTON, US, pages 37 - 38, XP002150694
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