Title:
IMMUNOMODULATING POLYMERS
Document Type and Number:
WIPO Patent Application WO2000059515
Kind Code:
A9
Abstract:
Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
Inventors:
TZIANABOS ARTHUR O
KASPER DENNIS L
ONDERDONK ANDREW B
WANG YING
KASPER DENNIS L
ONDERDONK ANDREW B
WANG YING
Application Number:
PCT/US2000/008586
Publication Date:
August 29, 2002
Filing Date:
March 31, 2000
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
A61K31/192; A61K31/7088; A61K31/715; A61K31/785; A61K35/26; A61K35/74; A61K38/00; A61K38/16; A61K38/20; A61K39/395; A61K45/00; A61K45/06; A61P1/04; A61P3/10; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C12N5/07; C12N5/0783; (IPC1-7): A61K31/7088; A61K38/00; A61K38/20; A61K39/395; A61P37/02
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