Title:
IMMUNOMODULATOR
Document Type and Number:
WIPO Patent Application WO/2022/007462
Kind Code:
A1
Abstract:
Disclosed in the present invention is an immunomodulator, specifically relating to a compound that inhibits IL-17A and the use thereof as an immunomodulator in the preparation of a drug. Disclosed in the present invention is the use of a compound as represented by formula I or a stereoisomer thereof in the preparation of a drug for inhibiting IL-17A, wherein same provides a new option for clinically screening and/or preparing a drug for treating diseases associated with IL-17A activity.
Inventors:
LI JIN (CN)
ZHANG DENGYOU (CN)
BAI XIAOGUANG (CN)
GONG YI (CN)
ZHOU XIANSI (CN)
LIU LICHUAN (CN)
LI QINGRAN (CN)
CHEN XIN (CN)
LAN YAN (CN)
ZHANG DENGYOU (CN)
BAI XIAOGUANG (CN)
GONG YI (CN)
ZHOU XIANSI (CN)
LIU LICHUAN (CN)
LI QINGRAN (CN)
CHEN XIN (CN)
LAN YAN (CN)
Application Number:
PCT/CN2021/087553
Publication Date:
January 13, 2022
Filing Date:
April 15, 2021
Export Citation:
Assignee:
HITGEN INC (CN)
International Classes:
C07D403/14; A61K31/4184; A61P29/00; C07D405/14; C07D413/14; C07D487/20
Domestic Patent References:
| WO2019223718A1 | 2019-11-28 | |||
| WO2019138017A1 | 2019-07-18 | |||
| WO2020127685A1 | 2020-06-25 |
Other References:
WRIGHT ET AL., JOURNAL OF IMMUNOLOGY, vol. 181, 2008, pages 2799 - 2805
AL-RAMLI ET AL., J ALLERGY CLIN IMMUNOL, vol. 123, 2009, pages 1185 - 1187
GAFFEN, SL ET AL., ARTHRITIS RESEARCH & THERAPY, vol. 6, 2004, pages 240 - 247
KOMIYAMA Y ET AL., J. IMMUNOL., vol. 177, 2006, pages 566 - 573
AL-RAMLI ET AL., J ALLERGY CLIN IMMUNOL, vol. 123, 2009, pages 1185 - 1187
GAFFEN, SL ET AL., ARTHRITIS RESEARCH & THERAPY, vol. 6, 2004, pages 240 - 247
KOMIYAMA Y ET AL., J. IMMUNOL., vol. 177, 2006, pages 566 - 573
Attorney, Agent or Firm:
WAYNE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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