Title:
IMMUNOPOTENTIATION COMPOSITION COMPRISING ARTEMISIA GMELINII EXTRACT
Document Type and Number:
WIPO Patent Application WO/2023/027527
Kind Code:
A1
Abstract:
The present invention relates to an immunopotentiation composition comprising an (Artemisia gmelinii extract as an active ingredient. Exhibiting immunopotentiation effects by proliferating T cells, increasing the production of the cytokines IL-2 and IFN-γ, the peritoneal macrophage-activating cytokines IL-6, TNF-α, and IL-12p70, and the immune cells whole blood cells (WBC), neutrophils, lymphocytes, and monocytes, upregulating the expression levels of serum IgG and fecal sIgA, and augmenting the activity of natural killer cells, the Artemisia gmelinii extract of the present invention can be advantageously used as an immunopotentiator. In addition, the Artemisia gmelinii extract of the present invention is stable in vivo because not causing cytotoxicity, and thus can also be utilized even in an immunopotentiation food composition, pharmaceutical composition, quasi-drug composition, or feed composition.
Inventors:
SHIN HEE SOON (KR)
KIM GUNDONG (KR)
KIM SEUNG YONG (KR)
SONG HYUN JI (KR)
SHIN DONG UK (KR)
EOM JIEUN (KR)
LEE SO YOUNG (KR)
IM KYUNG MIN (KR)
JUNG SUN YOUNG (KR)
PARK MIN KYUNG (KR)
KIM GUNDONG (KR)
KIM SEUNG YONG (KR)
SONG HYUN JI (KR)
SHIN DONG UK (KR)
EOM JIEUN (KR)
LEE SO YOUNG (KR)
IM KYUNG MIN (KR)
JUNG SUN YOUNG (KR)
PARK MIN KYUNG (KR)
Application Number:
PCT/KR2022/012741
Publication Date:
March 02, 2023
Filing Date:
August 25, 2022
Export Citation:
Assignee:
KOREA FOOD RES INST (KR)
International Classes:
A23L33/105; A23K10/30; A61K36/282; A61P35/00; A61P37/00
Foreign References:
| KR20210007460A | 2021-01-20 | |||
| KR20190133635A | 2019-12-03 | |||
| KR20170114796A | 2017-10-16 |
Other References:
SON SON YANG-JU YANG-JU, SHIN JI MIN, HA IN JIN, ERDENEBILEG SARUUL, JUNG DA SEUL, KIM YOUNG SIK, KIM SANG MIN, NHO CHU WON: "Identification of chemical compounds from Artemisia gmelinii using UPLC-QTOF-MS/MS and their regulatory effects on immune responses in DSS-induced colitis mice.", THE AMERICAN JOURNAL OF CHINESE MEDICINE, WORLD SCIENTIFIC, US, vol. 49, no. 4, 6 April 2021 (2021-04-06), US , pages 941 - 963, XP009543890, ISSN: 0192-415X, DOI: 10.1142/S0192415X21500452
QADIR MAHPARA, MAURYA ANTIM KUMAR, WAZA AJAZ AHMAD, AGNIHOTRI VIJAI KANT, SHAH WAJAHT A.: "Chemical composition, antioxidant and cytotoxic activity of Artemisia gmelinii essential oil growing wild in Kashmir valley", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, GB, vol. 34, no. 2, 1 January 2020 (2020-01-01), GB , pages 3289 - 3294, XP009543883, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1557178
LEE, MI KYOUNG, GUEN PYO CHOI, LEE HA RYU, GANG YOON LEE, CHANG YEON YU, HYEON YONG LEE: "Enhanced Immune Activity and Cytotoxicity of Artemisia capillaris Thunb. Extracts against Human ", CELL LINES. KOREAN JOURNAL OF MEDICINAL CROP SCIENCE., vol. 12, no. 1, 1 January 2004 (2004-01-01), pages 36 - 42, XP093039529
30 August 2009 (2009-08-30), HWANG, TAY-EAK: "Changes in Antioxidant Activity during Growth of Artemisia iwayomogi", XP053020062
NGUYEN THI VAN, PIAO CHUN HUA, FAN YAN JING, YU ZHEN NAN, LEE SO-YOUNG, SONG CHANG HO, SHIN HEE SOON, CHAI OK HEE: "Artemisia gmelinii Extract Alleviates Allergic Airway Inflammation via Balancing TH1/TH2 Homeostasis and Inhibiting Mast Cell Degranulation", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 23, 27 October 2021 (2021-10-27), pages 15377, XP093039540, DOI: 10.3390/ijms232315377
QADIR MAHPARA, MAURYA ANTIM KUMAR, WAZA AJAZ AHMAD, AGNIHOTRI VIJAI KANT, SHAH WAJAHT A.: "Chemical composition, antioxidant and cytotoxic activity of Artemisia gmelinii essential oil growing wild in Kashmir valley", NATURAL PRODUCT RESEARCH, TAYLOR AND FRANCIS HEALTH SCIENCES, ABINGDON, GB, vol. 34, no. 2, 1 January 2020 (2020-01-01), GB , pages 3289 - 3294, XP009543883, ISSN: 1478-6419, DOI: 10.1080/14786419.2018.1557178
LEE, MI KYOUNG, GUEN PYO CHOI, LEE HA RYU, GANG YOON LEE, CHANG YEON YU, HYEON YONG LEE: "Enhanced Immune Activity and Cytotoxicity of Artemisia capillaris Thunb. Extracts against Human ", CELL LINES. KOREAN JOURNAL OF MEDICINAL CROP SCIENCE., vol. 12, no. 1, 1 January 2004 (2004-01-01), pages 36 - 42, XP093039529
30 August 2009 (2009-08-30), HWANG, TAY-EAK: "Changes in Antioxidant Activity during Growth of Artemisia iwayomogi", XP053020062
NGUYEN THI VAN, PIAO CHUN HUA, FAN YAN JING, YU ZHEN NAN, LEE SO-YOUNG, SONG CHANG HO, SHIN HEE SOON, CHAI OK HEE: "Artemisia gmelinii Extract Alleviates Allergic Airway Inflammation via Balancing TH1/TH2 Homeostasis and Inhibiting Mast Cell Degranulation", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 23, 27 October 2021 (2021-10-27), pages 15377, XP093039540, DOI: 10.3390/ijms232315377
Attorney, Agent or Firm:
YOON & YANG (IP) LLC (KR)
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