Title:
IMMUNOREGULATORY AMIDE DERIVATIVE WITH IMPROVED MATERIAL PROPERTIES
Document Type and Number:
WIPO Patent Application WO/2023/014082
Kind Code:
A1
Abstract:
The present invention relates to a novel thalidomide-based compound derivative having significantly improved water solubility due to the introduction of a sugar or sugar derivative into lenalidomide or pomalidomide, which are thalidomide-based compounds, wherein the lenalidomide or pomalidomide derivative according to the present invention has significantly increased water solubility compared to conventional lenalidomide or pomalidomide and can thus be formulated into an injection or eye drop formulation. Therefore, the lenalidomide or pomalidomide derivative can be administered in the form of a high concentration therapeutic agent to a local area, and can be easily administered in combination with a different therapeutic agent developed as an injection or eye drop formulation.
Inventors:
KIM DONG SEOK (KR)
HWANG INHO (KR)
KIM YUKYUNG (KR)
KIM SUN (KR)
HWANG INHO (KR)
KIM YUKYUNG (KR)
KIM SUN (KR)
Application Number:
PCT/KR2022/011480
Publication Date:
February 09, 2023
Filing Date:
August 03, 2022
Export Citation:
Assignee:
AEVIS BIO INC (KR)
International Classes:
C07D401/04; A61K9/00; A61K9/14; A61K31/454; A61K31/706; A61K47/26; A61P17/06; A61P29/00; A61P35/00; C07H17/02
Foreign References:
| CN103421061A | 2013-12-04 | |||
| KR20170042598A | 2017-04-19 | |||
| KR20200078498A | 2020-07-01 | |||
| KR20190120094A | 2019-10-23 | |||
| US8686153B2 | 2014-04-01 | |||
| KR20200013258A | 2020-02-06 |
Other References:
IKAROSAIOLOS, SCIENCE, vol. 343, no. 301, 2014
A. R. GENNARO: "The Science and Practice of Pharmacy", 2006, LIPPINCOTT, WILLIAMS & WILKINS
A. R. GENNARO: "The Science and Practice of Pharmacy", 2006, LIPPINCOTT, WILLIAMS & WILKINS
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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