Title:
IMMUNOREGULATORY ISOLATE FROM COLOSTRUM
Document Type and Number:
WIPO Patent Application WO/1993/010801
Kind Code:
A1
Abstract:
An immunoregulatory isolate of mammalian colostrum is provided substantially free of cells and low density lipids and having inhibitory activity against cytokine synthesis by T lymphocytes which is not inhibited by antibodies to TGFbeta. Methods are also provided for producing immunosuppression in a mammal.
Inventors:
HOOTON JONATHAN (CA)
PABST HENRY F (CA)
PAETKAU VERNER F (CA)
SPADY DON (CA)
MANDALAPU PADMA (CA)
PABST HENRY F (CA)
PAETKAU VERNER F (CA)
SPADY DON (CA)
MANDALAPU PADMA (CA)
Application Number:
PCT/CA1992/000531
Publication Date:
June 10, 1993
Filing Date:
December 07, 1992
Export Citation:
Assignee:
UNIV ALBERTA (CA)
International Classes:
A61K35/20; (IPC1-7): A61K35/20
Other References:
Clin. exp. Immunol., Volume 86, 1991, J. W. L. Hooton et al., "Human colostrum contains an activity that inhibits the production of IL-2"
Clin. exp. Immunol., Volume 79, 1990, L. Mincheva-Nilsson et al., "Human milk contains proteins that stimulate and suppress T lymphocyte proliferation"
Clin. exp. Immunol., Volume 79, 1990, L. Mincheva-Nilsson et al., "Human milk contains proteins that stimulate and suppress T lymphocyte proliferation"
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