Title:
IMMUNOTHERAPEUTICS FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2003/030938
Kind Code:
A1
Abstract:
It is intended to provide a novel means for a novel immunotherapy under paying attention to the effects of activating NK cells, activating NKT cells, inhibiting angiogenesis, inducing IL−12 production and inducing IFN&gammad production. More specifically speaking, a novel use of immunotherapeutics for cancer characterized by comprising, to treat cancer depending on tissue and&sol or tissue type, classifying the treatment mechanisms at least into: (1) an effect of inhibiting angiogenesis&semi (2) an effect of inducing Th1 cytokines (TNF&agr , IFN&gammad and IL−12) and activating CTL&semi (3) increasing NK cells or activating the same&semi and (4) increasing NKT cells or activating the same, then measuring markers corresponding to respective effects, analyzing the measurement data depending on cancer tissue and&sol or tissue type, and thus selecting a prescription appropriate for the cancer tissue and&sol or tissue type.
Inventors:
YAGITA AKIKUNI (JP)
Application Number:
PCT/JP2002/010446
Publication Date:
April 17, 2003
Filing Date:
October 08, 2002
Export Citation:
Assignee:
ORIENT CANCER THERARY CO LTD (JP)
YAGITA AKIKUNI (JP)
YAGITA AKIKUNI (JP)
International Classes:
A61K31/00; A61K35/60; A61K49/00; A61P35/00; G01N33/50; G01N33/68; (IPC1-7): A61K45/00; A61P35/00; G01N33/50; G06F17/30
Domestic Patent References:
| WO2001070251A1 | 2001-09-27 | |||
| WO2001082935A1 | 2001-11-08 |
Foreign References:
| EP0844002A1 | 1998-05-27 | |||
| JP2001033460A | 2001-02-09 | |||
| JPH10147534A | 1998-06-02 | |||
| JP2001048795A | 2001-02-20 |
Other References:
AKIKUNI YAGITA ET AL.: "Shinsei kekkan sogaizai to naiinsei IL-12 to o mochiita shinmen'eki ryoho - partuclarly, NKT saibo no kan'yo ni tsuite", BIOTHERAPY, vol. 14, no. 5, 2000, pages 433 - 439, XP002961319
AKIKUNI YUGITA ET AL.: "Natural IL-12 yukizai no kakushu shinkogan ni taisuru sayo", BIOTHERAPY, vol. 14, no. 1, 2000, pages 33 - 37, XP002961320
AKIKUNI YAGITA ET AL.: "Shinmen'eki ryoho (kasho) (nobel immunotherapy for cancer; NITC) ni okeru kekkan shinsei sogaizai no yakuwari", BIOTHERAPY, vol. 14, no. 10, 2000, pages 973 - 981, XP002961321
SHOJI MARUYAMA ET AL.: "Shiko daichogan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, vol. 14, no. 5, 2000, pages 460 - 463, XP002961322
SHOJI MARUYAMA ET AL.: "Shinko igan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, no. 36, 1999, pages 59 - 62, XP002961323
SHOJI MARUYAMA ET AL.: "Shinko daichogan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, vol. 14, no. 1, May 2001 (2001-05-01), pages 48 - 50, XP002961324
AKIKUNI YAGITA ET AL.: "Shinmen'eki ryoho (NITC) ni okeru NKT-saibo no yakuwari", BIOTHERAPY, vol. 15, no. 3, May 2001 (2001-05-01), pages 403, XP002961325
AKIKUNI YAGITA ET AL.: "Human natural (Hn) IL-12 inducer o mochiita shinmen'eki ryoho", BIOTHERAPY, vol. 13, no. 1, 1999, pages 124, XP002961326
AKIKUNI YAGITA ET AL.: "IL-12 yuki busshitsu no AHCC to kekkan shinsei sohaizai to o mochiita BRM ryoho no kisoteki rinshoteki kento", BIOTHERAPY, vol. 12, no. 1, 1998, pages 38, XP002961327
AKIKUNI YUGITA ET AL.: "Natural IL-12 yukizai no kakushu shinkogan ni taisuru sayo", BIOTHERAPY, vol. 14, no. 1, 2000, pages 33 - 37, XP002961320
AKIKUNI YAGITA ET AL.: "Shinmen'eki ryoho (kasho) (nobel immunotherapy for cancer; NITC) ni okeru kekkan shinsei sogaizai no yakuwari", BIOTHERAPY, vol. 14, no. 10, 2000, pages 973 - 981, XP002961321
SHOJI MARUYAMA ET AL.: "Shiko daichogan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, vol. 14, no. 5, 2000, pages 460 - 463, XP002961322
SHOJI MARUYAMA ET AL.: "Shinko igan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, no. 36, 1999, pages 59 - 62, XP002961323
SHOJI MARUYAMA ET AL.: "Shinko daichogan ni okeru shinmen'eki ryoho no yukosei", BIOTHERAPY, vol. 14, no. 1, May 2001 (2001-05-01), pages 48 - 50, XP002961324
AKIKUNI YAGITA ET AL.: "Shinmen'eki ryoho (NITC) ni okeru NKT-saibo no yakuwari", BIOTHERAPY, vol. 15, no. 3, May 2001 (2001-05-01), pages 403, XP002961325
AKIKUNI YAGITA ET AL.: "Human natural (Hn) IL-12 inducer o mochiita shinmen'eki ryoho", BIOTHERAPY, vol. 13, no. 1, 1999, pages 124, XP002961326
AKIKUNI YAGITA ET AL.: "IL-12 yuki busshitsu no AHCC to kekkan shinsei sohaizai to o mochiita BRM ryoho no kisoteki rinshoteki kento", BIOTHERAPY, vol. 12, no. 1, 1998, pages 38, XP002961327
Attorney, Agent or Firm:
Shoji, Takashi (2-10 Iwamotocho 3-chom, Chiyoda-ku Tokyo, JP)
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