Title:
IMPLANTABLE BIOREACTOR AND METHODS FOR MAKING AND USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/071135
Kind Code:
A9
Abstract:
The present invention provides an implantable bioreactor comprising cells enclosed within an enclosure, said cells being capable of producing paracrine factors, wherein the enclosure is collapsible or expandable or both or neither, wherein the enclosure is semipermeable such that it provides containment of the cells preventing the egress of the cells while further providing a barrier that shields the cells from immunological attack, and wherein the enclosure is permeable to the entire secretome of the cell including exosomes, nucleic acids and proteins. The implantable bioreactor can have various configurations and can house internally a cell culture matrix than can include hydrogels, microbeads, and nanofiber matrices along with other active agents.
Inventors:
HWANG CHAO-WEI (US)
JOHNSTON PETER (US)
GERSTENBLITH GARY (US)
WEISS ROBERT G (US)
TOMASELLI GORDON (US)
SCHULMAN STEVEN (US)
JOHNSTON PETER (US)
GERSTENBLITH GARY (US)
WEISS ROBERT G (US)
TOMASELLI GORDON (US)
SCHULMAN STEVEN (US)
Application Number:
PCT/US2018/054623
Publication Date:
June 13, 2019
Filing Date:
October 05, 2018
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
A61M31/00; A61F2/02; A61K35/545; A61L31/04; A61L31/14; A61P9/00; C12N5/0775
Attorney, Agent or Firm:
CONTRERA, Joseph (US)
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