Title:
IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PRATICLES AS SCAFFOLDS FOR TISSUE REGENERATION
Document Type and Number:
WIPO Patent Application WO/2010/060104
Kind Code:
A3
Abstract:
In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.
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Inventors:
SCHUBERT SHAI YEHOSHUA (US)
Application Number:
PCT/US2009/065797
Publication Date:
October 28, 2010
Filing Date:
November 24, 2009
Export Citation:
Assignee:
MOMA THERAPEUTICS (US)
SCHUBERT SHAI YEHOSHUA (US)
SCHUBERT SHAI YEHOSHUA (US)
International Classes:
A61K51/12; A61K38/00; A61K38/39; A61L27/52; A61L27/54
Foreign References:
| US20050186240A1 | 2005-08-25 | |||
| US6398816B1 | 2002-06-04 |
Other References:
HOU, QINGPU ET AL.: "Injectable scaffolds for tissue regeneration", J. MATER. CHEM., vol. 14, 2004, pages 1915 - 1923, XP002610315
KOBSA, SERGE ET AL.: "Bioengineering Approaches to Controlled Protein Delivery", PEDIATRIC RESEARCH, vol. 63, no. 5, May 2008 (2008-05-01), pages 513 - 519, XP008166564
HO, EMILY ET AL.: "Synthesis and Characterization of an Injectable Hydrogel with Tunable Mechanical Properties for Soft Tissue Repair", BIOMACROMOLECULES, vol. 7, 2006, pages 3223 - 3228, XP008166561
See also references of EP 2370112A4
KOBSA, SERGE ET AL.: "Bioengineering Approaches to Controlled Protein Delivery", PEDIATRIC RESEARCH, vol. 63, no. 5, May 2008 (2008-05-01), pages 513 - 519, XP008166564
HO, EMILY ET AL.: "Synthesis and Characterization of an Injectable Hydrogel with Tunable Mechanical Properties for Soft Tissue Repair", BIOMACROMOLECULES, vol. 7, 2006, pages 3223 - 3228, XP008166561
See also references of EP 2370112A4
Attorney, Agent or Firm:
MILASINCIC, Debra, J. et al. (LlpOne Post Office Squar, Boston MA, US)
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