Title:
IMPROVED DELIVERY BY LABILE HYDROPHOBIC MODIFICATION OF DRUGS
Document Type and Number:
WIPO Patent Application WO2005026083
Kind Code:
A3
Abstract:
Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytically labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drag delivery, while lability minimizes entry of the drug into, non-target cells.
Inventors:
MONAHAN SEAN D (US)
SUBBOTIN VLADIMIR (US)
BUDKER VLADIMIR G (US)
NEAL ZANE C (US)
SUBBOTIN VLADIMIR (US)
BUDKER VLADIMIR G (US)
NEAL ZANE C (US)
Application Number:
PCT/US2004/028358
Publication Date:
May 12, 2005
Filing Date:
August 31, 2004
Export Citation:
Assignee:
MIRUS BIO CORP (US)
MONAHAN SEAN D (US)
SUBBOTIN VLADIMIR (US)
BUDKER VLADIMIR G (US)
NEAL ZANE C (US)
MONAHAN SEAN D (US)
SUBBOTIN VLADIMIR (US)
BUDKER VLADIMIR G (US)
NEAL ZANE C (US)
International Classes:
A61K9/00; A61K31/58; A61K31/695; C07F7/10; C07J1/00; (IPC1-7): C07C50/36; C07C233/02; C07D221/12; C07F7/02
Other References:
No relevant documents disclosed
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