Title:
IMPROVED DEVELOPMENTAL COMPETENCE OF OOCYTES
Document Type and Number:
WIPO Patent Application WO/2013/052995
Kind Code:
A3
Abstract:
The present disclosure relates to a method of improving developmental competence of an oocyte. The method comprises exposing the oocyte and/or an embryo to an endoplasmic reticulum stress inhibitor and/or an inducer of heat shock proteins.
Inventors:
ROBKER REBECCA LOUISE (AU)
WU LINDA LINYAN (AU)
WU LINDA LINYAN (AU)
Application Number:
PCT/AU2012/001219
Publication Date:
September 25, 2014
Filing Date:
October 10, 2012
Export Citation:
Assignee:
ADELAIDE RES & INNOVATION PTY (AU)
International Classes:
C12N5/075; A61P15/08
Other References:
WU, L. ET AL.: "Reduced Oocyte Quality and Poor Embryo Development Due to Dyslipidemia or Obesity Is Normalized By Blocking Endoplasmic Reticulum Stress", ENDOCR. REV., vol. 33, 2012
ROBKER, R. ET AL.: "Inflammatory pathways linking obesity and ovarian dysfunction", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 88, 2011, pages 142 - 148, XP028193744, DOI: doi:10.1016/j.jri.2011.01.008
WU, L. ET AL.: "The impact of obesity on oocytes: evidence for lipotoxicity mechanisms", REPRODUCTION, FERTILITY AND DEVELOPMENT, vol. 24, 2011, pages 29 - 34
PIRES ET AL.: "Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP 6 (380-389 ) of HSP90 beta protein", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 9, no. 16, 2011, pages 9
WU, L. ET AL.: "High-fat diet causes lipotoxicity Responses in cumulus-oocyte complexes and decreased ferilization rates", ENDOCRINOLOGY, vol. 151, no. 11, 2010, pages 5438 - 5445
HOTAMISLIGIL, G.S.: "Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease.", CELL, vol. 140, 2010, pages 900 - 917
ROBKER, R. ET AL.: "Inflammatory pathways linking obesity and ovarian dysfunction", JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 88, 2011, pages 142 - 148, XP028193744, DOI: doi:10.1016/j.jri.2011.01.008
WU, L. ET AL.: "The impact of obesity on oocytes: evidence for lipotoxicity mechanisms", REPRODUCTION, FERTILITY AND DEVELOPMENT, vol. 24, 2011, pages 29 - 34
PIRES ET AL.: "Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP 6 (380-389 ) of HSP90 beta protein", REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, vol. 9, no. 16, 2011, pages 9
WU, L. ET AL.: "High-fat diet causes lipotoxicity Responses in cumulus-oocyte complexes and decreased ferilization rates", ENDOCRINOLOGY, vol. 151, no. 11, 2010, pages 5438 - 5445
HOTAMISLIGIL, G.S.: "Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease.", CELL, vol. 140, 2010, pages 900 - 917
Attorney, Agent or Firm:
DIBBENS, Justin Andrew (Level 397 Pirie Stree, Adelaide South Australia 5000, AU)
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