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Title:
IMPROVED FIX FUSION PROTEIN AND CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/000767
Kind Code:
A1
Abstract:
Provided are a blood coagulation factor IX fusion protein with a prolonged circulation half-life, a conjugate thereof, a pharmaceutical composition containing same and the use of same in treating hemorrhagic diseases (such as hemophilia B).

Inventors:
SU HONGSHENG (CN)
CHEN XIAN (CN)
MO WEICHUAN (CN)
ZHU LUYAN (CN)
YAN HAIXIA (CN)
REN ZIJIA (CN)
WANG YALI (CN)
Application Number:
PCT/CN2020/097911
Publication Date:
January 07, 2021
Filing Date:
June 24, 2020
Export Citation:
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Assignee:
ZHENGZHOU GENSCIENCES INC (CN)
International Classes:
C07K19/00; A61K38/36; A61P7/04; C12N15/62; C12N15/63
Domestic Patent References:
WO2007135182A22007-11-29
WO2003040211A22003-05-15
Foreign References:
CN108137708A2018-06-08
CN108137708A2018-06-08
CN1422870A2003-06-11
CN104271150A2015-01-07
US5521070A1996-05-28
US6566506B22003-05-20
US6864350B22005-03-08
US6455639B12002-09-24
US5932462A1999-08-03
Other References:
"Genbank", Database accession no. NM_000133
LUND J. ET AL.: "Multiple binding sites on the CH2 domain of IgG for mouse Fc gamma Rll", MOL IMMUNOL, vol. 29, no. 1, January 1992 (1992-01-01), pages 53 - 9
"GenBank", Database accession no. NP_002560.1
PETERS ET AL.: "Prolonged activity of factor IX as a monomeric Fc fusion protein", BLOOD, vol. 115, no. 10, 2010, pages 2057 - 64, XP055201528, DOI: 10.1182/blood-2009-08-239665
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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