Title:
IMPROVED GENOME EDITING SYSTEM AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/004456
Kind Code:
A1
Abstract:
Provided is a genome edited fusion polypeptide, with same comprising a CRISPR nuclease domain and a transcription activation domain. Also provided are a polynucleotide and an expression construct encoding the fusion polypeptide, a genome editing system comprising the fusion polypeptide, polynucleotide and/or expression construct, and a method for editing the genome of a cell by means of the genome editing system.
Inventors:
QIU JIN-LONG (CN)
LIU GUANWEN (CN)
YIN KANGQUAN (CN)
LIU GUANWEN (CN)
YIN KANGQUAN (CN)
Application Number:
PCT/CN2020/100664
Publication Date:
January 14, 2021
Filing Date:
July 07, 2020
Export Citation:
Assignee:
INST MICROBIOLOGY CAS (CN)
International Classes:
C07K19/00; C12N5/10; C12N15/63; C12N15/82
Domestic Patent References:
| WO2019040650A1 | 2019-02-28 | |||
| WO2018148256A1 | 2018-08-16 |
Foreign References:
| CN105658805A | 2016-06-08 | |||
| CN107722125A | 2018-02-23 |
Other References:
GUANWEN LIU, YIN KANGQUAN, ZHANG QIANWEI, GAO CAIXIA, QIU JIN-LONG: "Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo", GENOME BIOLOGY, vol. 20, no. 1, 26 July 2019 (2019-07-26), pages 1 - 11, XP055771921, ISSN: 1465-6906, DOI: 10.1186/s13059-019-1762-8
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD (CN)
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