IMPROVED IN VIVO REPROGRAMMING SYSTEM AND CELL CONVERSION METHOD USING SAME

Title:

IMPROVED IN VIVO REPROGRAMMING SYSTEM AND CELL CONVERSION METHOD USING SAME

Document Type and Number:

WIPO Patent Application WO/2021/107530

Kind Code:

A1

Abstract:

The present invention relates to an improved in vivo reprogramming system, and a cell conversion method using same. A reprogramming system of the present invention comprises genes encoding a start cell marker promoter, a gene pluripotency-maintaining protein, an amino acid isolation peptide, Cre recombinase, an oriented cell marker promoter, LoxP, and a fluorescent protein, does not require the fixing of cells in order to confirm the conversion of the cells, enables the monitoring of cells in a living state in real time, and can be used both in vitro and in vivo. Therefore, the present invention is expected to be widely used in the biology and medical fields.

More Like This:

JP2001503279	Description: A novel construct and vector for targeting and inducing and expressing a gene.
WO/2002/079445	TRANSGENIC MICE CONTAINING KALLIKREIN-LIKE GENE DISRUPTIONS
WO/2004/028239	MAMMAL MODEL FOR AUTOIMMUNE DISEASES WITH DYSFUNCTION OF SOCS-1 GENE

Inventors:

HA YOON (KR)
LEE HYE LAN (KR)
LEE HYE YEONG (KR)

Application Number:

PCT/KR2020/016578

Publication Date:

June 03, 2021

Filing Date:

November 23, 2020

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV YONSEI IACF (KR)

International Classes:

C12N15/85; A61K48/00; A61P25/00; C07K14/47; C12N5/0793; C12Q1/02; G01N33/50

Foreign References:

JP2018513686A	2018-05-31
KR20190040479A	2019-04-18
KR20150105614A	2015-09-17
KR20140121787A	2014-10-16
KR101702629B1	2017-02-06

Other References:

HYEONHUI KIM, MINKI KIM, SUN-KYOUNG IM, SUNGSOON FANG: "Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes", LABORATORY ANIMAL RESEARCH, vol. 34, no. 4, 1 January 2018 (2018-01-01), pages 147 - 159, XP055713445, ISSN: 1738-6055, DOI: 10.5625/lar.2018.34.4.147
HUANG ET AL., NATURE, vol. 475, 2011, pages 386 - 389
BASSO DM ET AL., J NEUROTRAUMA, vol. 23, no. 5, May 2006 (2006-05-01), pages 635 - 59
LEE HL ET AL., J CONTROL RELEASE, vol. 226, 28 March 2016 (2016-03-28), pages 21 - 34
See also references of EP 4067494A4

Attorney, Agent or Firm:

LEE, Jae Young (KR)

Download PDF:

View/Download PDF PDF Help

Previous Patent: BATTERY MODULE, METHOD FOR MANUFACTURING SAME, AND BATTERY PACK

Next Patent: MASSAGE DEVICE PROVIDING TINNITUS TREATMENT PROGRAM AND CONTROL METHOD THEREFOR