Title:
AN IMPROVED METHOD FOR SYNTHESISING TEMPLATED MOLECULES
Document Type and Number:
WIPO Patent Application WO2003078625
Kind Code:
A3
Abstract:
The invention relates to a method for synthesising templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
Inventors:
PEDERSEN HENRIK (DK)
HOLTMANN ANETTE (DK)
FRANCH THOMAS (DK)
GOULIAEV ALEX HAAHR (DK)
FELDING JAKOB (DK)
HOLTMANN ANETTE (DK)
FRANCH THOMAS (DK)
GOULIAEV ALEX HAAHR (DK)
FELDING JAKOB (DK)
Application Number:
PCT/DK2003/000172
Publication Date:
January 08, 2004
Filing Date:
March 14, 2003
Export Citation:
Assignee:
NUEVOLUTION AS (DK)
PEDERSEN HENRIK (DK)
HOLTMANN ANETTE (DK)
FRANCH THOMAS (DK)
GOULIAEV ALEX HAAHR (DK)
FELDING JAKOB (DK)
PEDERSEN HENRIK (DK)
HOLTMANN ANETTE (DK)
FRANCH THOMAS (DK)
GOULIAEV ALEX HAAHR (DK)
FELDING JAKOB (DK)
International Classes:
F03D9/00; C07B61/00; C07D405/04; C07H21/00; C12N15/10; C12P1/00; C12P19/34; H02P9/00; C12Q1/68; C07B; C07H; C12N; C12P; (IPC1-7): C12N15/10; C12P1/00; C07H21/00; C07B61/00
Domestic Patent References:
| WO2002074929A2 | 2002-09-26 | |||
| WO2000061775A1 | 2000-10-19 | |||
| WO1998056904A1 | 1998-12-17 |
Other References:
GARTNER Z J ET AL: "The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. UNITED STATES 18 JUL 2001, vol. 123, no. 28, 18 July 2001 (2001-07-18), pages 6961 - 6963, XP001127054, ISSN: 0002-7863
SUMMERER DANIEL ET AL: "DNA-templated synthesis: more versatile than expected.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) GERMANY 4 JAN 2002, vol. 41, no. 1, 4 January 2002 (2002-01-04), pages 89 - 90, XP001170352, ISSN: 0570-0833
MATSUURA K ET AL: "Construction of glyco-clusters by self-organization of site-specifically glycosylated oligonucleotides and their cooperative amplification of lectin-recognition.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. UNITED STATES 17 JAN 2001, vol. 123, no. 2, 17 January 2001 (2001-01-17), pages 357 - 358, XP002258330, ISSN: 0002-7863
VISSCHER J ET AL: "TEMPLATE-DIRECTED SYNTHESIS OF ACYCLIC OLIGONUCLEOTIDE ANALOGUES", JOURNAL OF MOLECULAR EVOLUTION, SPRINGER VERLAG, NEW YORK, NY, US, vol. 28, no. 1/2, 1988, pages 3 - 6, XP000857353, ISSN: 0022-2844
BRENNER S ET AL: "ENCODED COMBINATORIAL CHEMISTRY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, no. 12, 1 June 1992 (1992-06-01), pages 5381 - 5383, XP000647936, ISSN: 0027-8424
SUMMERER DANIEL ET AL: "DNA-templated synthesis: more versatile than expected.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) GERMANY 4 JAN 2002, vol. 41, no. 1, 4 January 2002 (2002-01-04), pages 89 - 90, XP001170352, ISSN: 0570-0833
MATSUURA K ET AL: "Construction of glyco-clusters by self-organization of site-specifically glycosylated oligonucleotides and their cooperative amplification of lectin-recognition.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. UNITED STATES 17 JAN 2001, vol. 123, no. 2, 17 January 2001 (2001-01-17), pages 357 - 358, XP002258330, ISSN: 0002-7863
VISSCHER J ET AL: "TEMPLATE-DIRECTED SYNTHESIS OF ACYCLIC OLIGONUCLEOTIDE ANALOGUES", JOURNAL OF MOLECULAR EVOLUTION, SPRINGER VERLAG, NEW YORK, NY, US, vol. 28, no. 1/2, 1988, pages 3 - 6, XP000857353, ISSN: 0022-2844
BRENNER S ET AL: "ENCODED COMBINATORIAL CHEMISTRY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, no. 12, 1 June 1992 (1992-06-01), pages 5381 - 5383, XP000647936, ISSN: 0027-8424
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