Title:
IMPROVED METHODS FOR SYNTHESIS OF OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO2002062811
Kind Code:
A3
Abstract:
The present invention is directed to improved methods and compositions for synthesis of oligonucleotides and other phosphorus-linked oligomers, without the need for phosphoryl protecting groups. The methods involve the reaction of nucleoside phosphoramidites with a support-bound oligomer having one or more unprotected phosphorus containing internucleoside linkages in the presence of a neutralizing agent.
Inventors:
GUZAEV ANDREI P (US)
MANOHARAN MUTHIAH (US)
MANOHARAN MUTHIAH (US)
Application Number:
PCT/US2002/002336
Publication Date:
November 06, 2003
Filing Date:
January 28, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
GUZAEV ANDREI P (US)
MANOHARAN MUTHIAH (US)
GUZAEV ANDREI P (US)
MANOHARAN MUTHIAH (US)
International Classes:
C07H19/10; C07H19/20; C07H21/00; C08F2/00; (IPC1-7): C07H19/04
Foreign References:
| US6465628B1 | 2002-10-15 | |||
| US5959090A | 1999-09-28 | |||
| US6121437A | 2000-09-19 |
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