Title:
AN IMPROVED PROCESS FOR THE PREPARATION OF ENFUVIRTIDE
Document Type and Number:
WIPO Patent Application WO/2011/095989
Kind Code:
A3
Abstract:
The present invention relates to a novel process for the synthesis of Enfuvirtide or pharmaceutically acceptable salts by using a hybrid approach. The fragments are synthesized by solid phase synthesis approach and the Enfuvirtide is synthesized by making use of the fragments in solution phase.
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Inventors:
KUPPANNA ANANDA
KOMMA REDDY MARIA BHASKAR REDDY
DATTA DEBASHISH
KOMMA REDDY MARIA BHASKAR REDDY
DATTA DEBASHISH
Application Number:
PCT/IN2011/000074
Publication Date:
January 12, 2012
Filing Date:
February 02, 2011
Export Citation:
Assignee:
MATRIX LAB LTD (IN)
KUPPANNA ANANDA
KOMMA REDDY MARIA BHASKAR REDDY
DATTA DEBASHISH
KUPPANNA ANANDA
KOMMA REDDY MARIA BHASKAR REDDY
DATTA DEBASHISH
International Classes:
C07K14/435
Domestic Patent References:
| WO1999048513A1 | 1999-09-30 | |||
| WO2005089796A1 | 2005-09-29 |
Foreign References:
| US5464933A | 1995-11-07 |
Other References:
BRAY B L: "LARGE-SCALE MANUFACTURE OF PEPTIDE THERAPEUTICS BY CHEMICAL SYNTHESIS", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 2, no. 7, 1 July 2003 (2003-07-01), pages 587 - 593, XP009046605, ISSN: 1474-1784, DOI: 10.1038/NRD1133
LEE ET AL: "Application of AM SURE(TM) resin to solid-phase peptide synthesis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 42, 17 October 2005 (2005-10-17), pages 7135 - 7138, XP005077503, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2005.08.093
NAKAMURA M ET AL: "DESIGN AND SYNTHESIS OF HIGHLY ACTIVE ANTI-HIV PEPTIDE BASED ON GP41-C34 PEPTIDE", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO, JP, 3 October 2001 (2001-10-03), pages 73 - 76, XP008018872, ISSN: 1344-7661
LAWLESS M K ET AL: "HIV-1 MEMBRANE FUSION MECHANISM: STRUCTURAL STUDIES OF THE INTERACTIONS BETWEEN BIOLOGICALLY-ACTIVE PEPTIDES FROM GP41", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 42, 22 October 1996 (1996-10-22), pages 13697 - 13708, XP002059093, ISSN: 0006-2960, DOI: 10.1021/BI9606962
LEE ET AL: "Application of AM SURE(TM) resin to solid-phase peptide synthesis", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 42, 17 October 2005 (2005-10-17), pages 7135 - 7138, XP005077503, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2005.08.093
NAKAMURA M ET AL: "DESIGN AND SYNTHESIS OF HIGHLY ACTIVE ANTI-HIV PEPTIDE BASED ON GP41-C34 PEPTIDE", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO, JP, 3 October 2001 (2001-10-03), pages 73 - 76, XP008018872, ISSN: 1344-7661
LAWLESS M K ET AL: "HIV-1 MEMBRANE FUSION MECHANISM: STRUCTURAL STUDIES OF THE INTERACTIONS BETWEEN BIOLOGICALLY-ACTIVE PEPTIDES FROM GP41", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35, no. 42, 22 October 1996 (1996-10-22), pages 13697 - 13708, XP002059093, ISSN: 0006-2960, DOI: 10.1021/BI9606962
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