Title:
IMPROVED PROCESS FOR PRODUCING 1, 5-PENTAMETHYLENE DIISOCYANATE FROM CADAVERINE SALT
Document Type and Number:
WIPO Patent Application WO/2022/073506
Kind Code:
A1
Abstract:
An improved process for producing 1, 5-pentamethylene diisocyanate (PDI) from a cadaverine salt is described herein. The process generally comprises providing a solution comprising a cadaverine salt dissolved in an inert solvent in the presence of a tertiary amine base; and subjecting the solution to a liquid-phase phosgenation reaction to convert the cadaverine to PDI. The phosgenation reaction comprises a step of maintaining the reaction at temperatures between 100 ℃ and 120 ℃ for a sufficient time to achieve a desired threshold yield of PDI. The processes described herein enable reductions in the amounts of reactants consumed, reaction temperatures, and/or overall reaction time, as compared to conventional phosgenation reactions. Employing a bio-based cadaverine salt that was not previously subjected to distillation is found to be advantageous, since subjecting cadaverine to high temperatures leads to the formation of certain cyclic compounds that are carried over to the PDI produced.
Inventors:
LAU MAN KIT (CN)
LU CHENGLIANG (CN)
CHIEW ANSEN (CN)
LU CHENGLIANG (CN)
CHIEW ANSEN (CN)
Application Number:
PCT/CN2021/122833
Publication Date:
April 14, 2022
Filing Date:
October 09, 2021
Export Citation:
Assignee:
MOJIA BIOTECH LTD (CN)
International Classes:
C07C263/04; C07C263/20; C07C265/14
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Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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