Title:
IMPROVEMENT IN THE LIGAND PROTECTION FOR MERCAPTOACETYL TRIGLYCINE
Document Type and Number:
WIPO Patent Application WO2005079864
Kind Code:
A3
Abstract:
The present invention relates to a method for preparing mercaptoacetyl triglycine labeled with a radionuclide, comprising the steps of adding a radionuclide to a solution that comprises a mercaptoacetyl triglycine dimer of formula VI, a reducing agent and optionally a transfer ligand and heating the thus obtained solution. The invention relates to the mercaptoacetyl triglycine dimer and its use in the method, to a kit for performing the method and to the formulation obtained from the method.
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Inventors:
BLAUWHOFF MART-JAN T (DE)
KNIGHT HECTOR H (NL)
STOCK FRIEDHELM R (NL)
VERKERK VOLCMAR (NL)
KNIGHT HECTOR H (NL)
STOCK FRIEDHELM R (NL)
VERKERK VOLCMAR (NL)
Application Number:
PCT/US2005/004349
Publication Date:
January 19, 2006
Filing Date:
February 11, 2005
Export Citation:
Assignee:
MALLINCKRODT INC (US)
BLAUWHOFF MART-JAN T (DE)
KNIGHT HECTOR H (NL)
STOCK FRIEDHELM R (NL)
VERKERK VOLCMAR (NL)
BLAUWHOFF MART-JAN T (DE)
KNIGHT HECTOR H (NL)
STOCK FRIEDHELM R (NL)
VERKERK VOLCMAR (NL)
International Classes:
A61K51/08; A61K51/12; C07B59/00; (IPC1-7): A61K51/08; C07B59/00
Foreign References:
| EP0483704A1 | 1992-05-06 |
Other References:
STALTERI M A ET AL: "COMPARISON OF THE STABILITY OF TECHNETIUM-LABELED PEPTIDES TO CHALLENGE WITH CYSTEINE", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 10, no. 1, January 1999 (1999-01-01), pages 130 - 136, XP009003810, ISSN: 1043-1802
NOLL B ET AL: "Sources of radiochemical impurities in the <99m>TcS-unprotected MAG3 system", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 22, no. 8, November 1995 (1995-11-01), pages 1057 - 1062, XP004051713, ISSN: 0969-8051
BORMANS G ET AL: "Investigation of the Labelling Characteristics of <99m>Tc-Mercaptoacetyltriglycine", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 22, no. 3, April 1995 (1995-04-01), pages 339 - 349, XP004051796, ISSN: 0969-8051
NOLL B ET AL: "Sources of radiochemical impurities in the <99m>TcS-unprotected MAG3 system", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 22, no. 8, November 1995 (1995-11-01), pages 1057 - 1062, XP004051713, ISSN: 0969-8051
BORMANS G ET AL: "Investigation of the Labelling Characteristics of <99m>Tc-Mercaptoacetyltriglycine", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 22, no. 3, April 1995 (1995-04-01), pages 339 - 349, XP004051796, ISSN: 0969-8051
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