Title:
IMPROVEMENT OF RENAL HYPOFUNCTION BY SUBSTANCE HAVING AMMONIA EXCRETION-PROMOTING EFFECT
Document Type and Number:
WIPO Patent Application WO/2024/095992
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel means for suppressing renal hypofunction, the means being capable of fundamentally improving diseases associated with renal hypofunction, including chronic kidney disease (CKD). The present inventors solved the aforesaid problem by providing a novel means for suppressing renal hypofunction, the means suppressing and/or improving renal hypofunction in a living body using a substance having ammonia excretion-promoting effect. More specifically, the present invention solved the aforesaid problem by providing a renal hypofunction suppressing agent that contains a substance having ammonia excretion-promoting effect in a living body.
Inventors:
KAMIMOTO TAKAHASHI SHOKO (JP)
SAITO KENJI (JP)
SAITO KENJI (JP)
Application Number:
PCT/JP2023/039194
Publication Date:
May 10, 2024
Filing Date:
October 31, 2023
Export Citation:
Assignee:
TAZ INC (JP)
International Classes:
A61K45/00; A23L33/125; A23L33/175; A61K31/192; A61K31/198; A61K31/7016; A61P13/12; A61P43/00
Domestic Patent References:
| WO2023182475A1 | 2023-09-28 |
Foreign References:
| JP2016069317A | 2016-05-09 |
Other References:
AOYAGI, KAZUMASA ET AL.: "Nutritional therapy and exercise therapy for sarcopenia and frailty in the presence of CKD", KIDNEY AND DIALYSIS, vol. 90, no. 3, 2021, pages 409 - 416
HAMID TAYEBI-KHOSROSHAHI: "The effect of lactulose supplementation on fecal microflora of patients with chronic kidney disease; a randomized clinical trial", JOURNAL OF RENAL INJURY PREVENTION, vol. 5, no. 3, pages 162 - 167, XP093166313, ISSN: 2345-2781, DOI: 10.15171/jrip.2016.34
SUEYOSHI MIYU; FUKUNAGA MASAKI; MEI MIZUE; NAKAJIMA ATSUSHI; TANAKA GAKU; MURASE TAKAYO; NARITA YUKI; HIRATA SUMIO; KADOWAKI DAISU: "Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats", CLINICAL AND EXPERIMENTAL NEPHROLOGY, JAPANESE SOCIETY OF NEPHROLOGY, TOKYO,, JP, vol. 23, no. 7, 20 March 2019 (2019-03-20), JP , pages 908 - 919, XP036799672, ISSN: 1342-1751, DOI: 10.1007/s10157-019-01727-4
M. SATOH: "SUN-158 EFFECT OF UREMIC TOXIN-INDOXYL SULFATE ON INTESTINAL DEFENSIN EXPRESSION IN RENAL FAILURE MICE.", KIDNEY INTERNATIONAL REPORTS, ELSEVIER INC., US, vol. 4, no. 7, 1 July 2019 (2019-07-01), US , pages S223, XP093166316, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2019.05.559
RUSZKOWSKI JAKUB; WITKOWSKI JACEK M.: "Lactulose: Patient- and dose-dependent prebiotic properties in humans", ANAEROBE, ELSEVIER, AMSTERDAM, NL, vol. 59, 5 June 2019 (2019-06-05), AMSTERDAM, NL, pages 100 - 106, XP085852035, ISSN: 1075-9964, DOI: 10.1016/j.anaerobe.2019.06.002
HAMID TAYEBI-KHOSROSHAHI: "The effect of lactulose supplementation on fecal microflora of patients with chronic kidney disease; a randomized clinical trial", JOURNAL OF RENAL INJURY PREVENTION, vol. 5, no. 3, pages 162 - 167, XP093166313, ISSN: 2345-2781, DOI: 10.15171/jrip.2016.34
SUEYOSHI MIYU; FUKUNAGA MASAKI; MEI MIZUE; NAKAJIMA ATSUSHI; TANAKA GAKU; MURASE TAKAYO; NARITA YUKI; HIRATA SUMIO; KADOWAKI DAISU: "Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats", CLINICAL AND EXPERIMENTAL NEPHROLOGY, JAPANESE SOCIETY OF NEPHROLOGY, TOKYO,, JP, vol. 23, no. 7, 20 March 2019 (2019-03-20), JP , pages 908 - 919, XP036799672, ISSN: 1342-1751, DOI: 10.1007/s10157-019-01727-4
M. SATOH: "SUN-158 EFFECT OF UREMIC TOXIN-INDOXYL SULFATE ON INTESTINAL DEFENSIN EXPRESSION IN RENAL FAILURE MICE.", KIDNEY INTERNATIONAL REPORTS, ELSEVIER INC., US, vol. 4, no. 7, 1 July 2019 (2019-07-01), US , pages S223, XP093166316, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2019.05.559
RUSZKOWSKI JAKUB; WITKOWSKI JACEK M.: "Lactulose: Patient- and dose-dependent prebiotic properties in humans", ANAEROBE, ELSEVIER, AMSTERDAM, NL, vol. 59, 5 June 2019 (2019-06-05), AMSTERDAM, NL, pages 100 - 106, XP085852035, ISSN: 1075-9964, DOI: 10.1016/j.anaerobe.2019.06.002
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
Download PDF: