Title:
IMPROVEMENTS IN PHARMACEUTICAL COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2003051893
Kind Code:
A3
Abstract:
Compounds of formula (I) or (II), wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton, and R1 is a substituted or unsubstituted, branched or straight chain alkyl, alkenyl, or alkynyl group, that contains 1-12 carbon atoms, and there use in therapeutic methods.
Inventors:
ROBERTS STANLEY MICHAEL (GB)
HAPPE ALAN MICHAEL (GB)
SANTORO MARIA GABRIELLA (IT)
HAPPE ALAN MICHAEL (GB)
SANTORO MARIA GABRIELLA (IT)
Application Number:
PCT/GB2002/005709
Publication Date:
September 18, 2003
Filing Date:
December 16, 2002
Export Citation:
Assignee:
CHARTERHOUSE THERAPEUTICS LTD (GB)
ROBERTS STANLEY MICHAEL (GB)
HAPPE ALAN MICHAEL (GB)
SANTORO MARIA GABRIELLA (IT)
ROBERTS STANLEY MICHAEL (GB)
HAPPE ALAN MICHAEL (GB)
SANTORO MARIA GABRIELLA (IT)
International Classes:
A61P3/02; A61K31/122; A61P3/10; A61P9/10; A61P17/02; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/02; A61P39/00; A61P39/06; A61P43/00; C07C45/30; C07C49/647; C07C49/753; C07C321/22; C07C323/22; C07F7/18; (IPC1-7): C07F49/647; A61K31/122; A61P25/28; C07C323/22
Domestic Patent References:
| WO2000056341A1 | 2000-09-28 | |||
| WO2001044254A1 | 2001-06-21 |
Foreign References:
| DE2439089A1 | 1975-03-13 |
Other References:
X. ZHANG, ET AL.: "Studies on cyclopent-2-enone. IV. Preparations of unsaturated delta-lactones from the aldols of cyclopent-2-enone", CHINESE CHEMICAL LETTERS, vol. 2, no. 12, 1991, Springer, SG, pages 919 - 920, XP008017780, ISSN: 1001-8417
M. POHMAKOTR, ET AL.: "Intramolecular acylation of alpha-sulphinyl carbanion: a new general route to 5-substituted delta2-cyclopentenones", TETRAHEDRON LETTERS, vol. 25, no. 21, 1984, Elsevier Science Publishers, Amsterdam, NL, pages 2249 - 2252, XP002242071, ISSN: 0040-4039
H.J. REICH, ET AL.: "Organoselenium chemistry. Conversion of cyclic ketones and beta-dicarbonyl compounds to enones", JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 14, 12 July 1974 (1974-07-12), American Chemical Society, Washington, DC, US, pages 2133 - 2135, XP000576070, ISSN: 0022-3263
P.A. GRIECO, ET AL.: "Synthesis of 5-alkyl-delta2-cyclopentenones and 6-alkyl-delta2-cyclohexanones", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, 5 February 1975 (1975-02-05), Royal Society of Chemistry, Letchworth, GB, pages 72 - 73, XP002242072, ISSN: 0022-4936
K. BIGGADIKE, ET AL.: "Use of diethylaminosulphur trifuoride (DAST) in the preparation of synthons of carbocyclic nucleosides", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 3, March 1988 (1988-03-01), Royal Society of Chemistry, Letchworth, GB, pages 549 - 554, XP000573904, ISSN: 0300-922X
J. TSUJI, ET AL.: "Allylic carbonates. Efficient allylating agents of carbonucleophiles in palladium-catalysed reactions under neutral conditions", JOURNAL OF ORGANIC CHEMISTRY, vol. 50, no. 9, 3 May 1985 (1985-05-03), American Chemical Society, Washington, DC, US, pages 1523 - 1529, XP002242073, ISSN: 0022-3263
K. NAKATANI, ET AL.: "Intramolecular cooperative reactions of 1,2-bis(diazoketone)s. The first synthesis of trans-hydro-1H-inden-1-ones", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 8, 21 April 1995 (1995-04-21), American Chemical Society, Washington, DC, US, pages 2466 - 2473, XP002242074, ISSN: 0022-3263
G. PANDEY, ET AL.: "The intermolecular beta-coupling of cyclic enones with activated alkenes and alkynes: unexpected beta-alkoxy elimination from a 4-alkoxy-2-alkyl-1-hydroxy-cyclopentenyl radical", TETRAHEDRON LETTERS, vol. 39, no. 45, 5 November 1998 (1998-11-05), Elsevier Science Publishers, Amsterdam, NL, pages 8341 - 8344, XP004139412, ISSN: 0040-4039
M. POHMAKOTR, ET AL.: "Intramolecular acylation of alpha-sulphinyl carbanion: a new general route to 5-substituted delta2-cyclopentenones", TETRAHEDRON LETTERS, vol. 25, no. 21, 1984, Elsevier Science Publishers, Amsterdam, NL, pages 2249 - 2252, XP002242071, ISSN: 0040-4039
H.J. REICH, ET AL.: "Organoselenium chemistry. Conversion of cyclic ketones and beta-dicarbonyl compounds to enones", JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 14, 12 July 1974 (1974-07-12), American Chemical Society, Washington, DC, US, pages 2133 - 2135, XP000576070, ISSN: 0022-3263
P.A. GRIECO, ET AL.: "Synthesis of 5-alkyl-delta2-cyclopentenones and 6-alkyl-delta2-cyclohexanones", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, 5 February 1975 (1975-02-05), Royal Society of Chemistry, Letchworth, GB, pages 72 - 73, XP002242072, ISSN: 0022-4936
K. BIGGADIKE, ET AL.: "Use of diethylaminosulphur trifuoride (DAST) in the preparation of synthons of carbocyclic nucleosides", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 3, March 1988 (1988-03-01), Royal Society of Chemistry, Letchworth, GB, pages 549 - 554, XP000573904, ISSN: 0300-922X
J. TSUJI, ET AL.: "Allylic carbonates. Efficient allylating agents of carbonucleophiles in palladium-catalysed reactions under neutral conditions", JOURNAL OF ORGANIC CHEMISTRY, vol. 50, no. 9, 3 May 1985 (1985-05-03), American Chemical Society, Washington, DC, US, pages 1523 - 1529, XP002242073, ISSN: 0022-3263
K. NAKATANI, ET AL.: "Intramolecular cooperative reactions of 1,2-bis(diazoketone)s. The first synthesis of trans-hydro-1H-inden-1-ones", JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 8, 21 April 1995 (1995-04-21), American Chemical Society, Washington, DC, US, pages 2466 - 2473, XP002242074, ISSN: 0022-3263
G. PANDEY, ET AL.: "The intermolecular beta-coupling of cyclic enones with activated alkenes and alkynes: unexpected beta-alkoxy elimination from a 4-alkoxy-2-alkyl-1-hydroxy-cyclopentenyl radical", TETRAHEDRON LETTERS, vol. 39, no. 45, 5 November 1998 (1998-11-05), Elsevier Science Publishers, Amsterdam, NL, pages 8341 - 8344, XP004139412, ISSN: 0040-4039
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