Title:
IMPURITIES OF AMIDE DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/125580
Kind Code:
A1
Abstract:
An impurity A, an impurity B, and an impurity C and preparation methods therefor, and an application as a reference standard for quality control of a compound as represented by formula VI.
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Inventors:
DOU FEI (CN)
JING PENG (CN)
JING PENG (CN)
Application Number:
PCT/CN2019/125643
Publication Date:
June 25, 2020
Filing Date:
December 16, 2019
Export Citation:
Assignee:
NHWA PHARMA CORP (CN)
International Classes:
C07D413/14; C07D217/00; C07D221/04; C07D401/12; C07D403/12
Domestic Patent References:
| WO2018118734A1 | 2018-06-28 | |||
| WO2017084627A1 | 2017-05-26 |
Foreign References:
| CN106749219A | 2017-05-31 | |||
| CN101506171A | 2009-08-12 |
Other References:
HANG, TAIJUN : " Drug impurity testing", PHARMACEUTICAL ANALYSIS, 31 August 2011 (2011-08-31)
JANGIR, R. ET AL.: "Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine", SYNTHESIS, vol. 46, no. 14, 10 April 2014 (2014-04-10), XP055715370, ISSN: 0039-7881, DOI: 20200109181816Y
TROST BARRY M., KALNMALS CHRISTOPHER A.: "Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3-sp2 and sp2-sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 36, 15 March 2018 (2018-03-15), pages 9066 - 9074, XP055827431, ISSN: 0947-6539, DOI: 10.1002/chem.201800118
See also references of EP 3901149A4
JANGIR, R. ET AL.: "Facile Synthesis of the Isoquinoline Alkaloids Doryanine and Oxyhydrastinine", SYNTHESIS, vol. 46, no. 14, 10 April 2014 (2014-04-10), XP055715370, ISSN: 0039-7881, DOI: 20200109181816Y
TROST BARRY M., KALNMALS CHRISTOPHER A.: "Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3-sp2 and sp2-sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds", CHEMISTRY - A EUROPEAN JOURNAL, vol. 24, no. 36, 15 March 2018 (2018-03-15), pages 9066 - 9074, XP055827431, ISSN: 0947-6539, DOI: 10.1002/chem.201800118
See also references of EP 3901149A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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