Title:
INCREASED FUNCTIONAL ACTIVITY AND/OR EXPRESSION OF ABC TRANSPORTERS PROTECTS AGAINST THE LOSS OF DOPAMINE NEURONS ASSOCIATED WITH PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO2002094378
Kind Code:
A3
Abstract:
Methods and compositions are provided for reducing the level of a catecholamine, in particular dopamine, and conjugates thereof, thus reducing catecholaminergic cell toxicity, by increasing a functional activity or increasing expression of ABC transporter polypeptides. ABC transporters serve to extrude dopamine and dopamine conjugates out of the neuron, thus preventing or reducing dopamine-associated toxicity, including cell death. Agents that increase a level of expression, or increase a functional activity, or increase both, of the ABC transporters find utility in preventing or alleviating Parkinson's disease.
Inventors:
REINER PETER B (CA)
ROY JOSEE (CA)
CONNOP BRUCE P (CA)
ROY JOSEE (CA)
CONNOP BRUCE P (CA)
Application Number:
PCT/CA2002/000729
Publication Date:
February 05, 2004
Filing Date:
May 22, 2002
Export Citation:
Assignee:
ACTIVE PASS PHARMACEUTICALS IN (CA)
REINER PETER B (CA)
ROY JOSEE (CA)
CONNOP BRUCE P (CA)
REINER PETER B (CA)
ROY JOSEE (CA)
CONNOP BRUCE P (CA)
International Classes:
A61K49/00; A61P25/16; C07K14/705; G01N33/68; G01N33/94; A61K38/00; A61K48/00; (IPC1-7): A61P25/16; A01K67/027; A61K38/17; A61K48/00; A61K49/00; C07K14/705; C12Q1/68; G01N33/50
Domestic Patent References:
| WO2001014547A1 | 2001-03-01 | |||
| WO1993024628A2 | 1993-12-09 |
Other References:
LAMENSDORF ITSCHAK ET AL: "Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter.", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 361, no. 6, June 2000 (2000-06-01), pages 654 - 664, XP002251683, ISSN: 0028-1298
SPERLAGH BEATA ET AL: "Ischemic-like condition releases norepinephrine and purines from different sources in superfused rat spleen strips.", JOURNAL OF NEUROIMMUNOLOGY, vol. 111, no. 1-2, 1 November 2000 (2000-11-01), pages 45 - 54, XP002251684, ISSN: 0165-5728
SPERLAGH BEATA ET AL: "Ischemic-like condition releases norepinephrine and purines from different sources in superfused rat spleen strips.", JOURNAL OF NEUROIMMUNOLOGY, vol. 111, no. 1-2, 1 November 2000 (2000-11-01), pages 45 - 54, XP002251684, ISSN: 0165-5728
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