INDAZOLE AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Title:

INDAZOLE AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/035019

Kind Code:

A1

Abstract:

The present invention relates to an indazole derivative as shown in general formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and the use thereof as a therapeutic agent, especially as an IRAK4 kinase inhibitor. The definitions of R1, R2, R3 and W in general formula (I) are the same as those in the description.

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Inventors:

ZHAI WENQIANG (CN)
LU YONGPING (CN)
YUN HONGWEI (CN)
LIN HAIMING (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
SHI ZHENGZHENG (CN)
HU TAISHAN (CN)
CHEN LEI (CN)

Application Number:

PCT/CN2019/100760

Publication Date:

February 20, 2020

Filing Date:

August 15, 2019

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Assignee:

ZHEJIANG HISUN PHARM CO LTD (CN)

International Classes:

C07D401/12; A61K31/4439; A61P15/00; A61P17/00; A61P19/02; A61P29/00; A61P35/00; A61P37/02; C07D401/14

Domestic Patent References:

WO2017148902A1	2017-09-08
WO2017108744A1	2017-06-29

Foreign References:

CN107406416A	2017-11-28
CN106458982A	2017-02-22

Attorney, Agent or Firm:

SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)

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