Title:
INDAZOLE DERIVATIVES THAT ARE ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE
Document Type and Number:
WIPO Patent Application WO2003076408
Kind Code:
A3
Abstract:
Compounds of formula (I) are novel indazoles useful for increasing cGMP levels in a mammal.
Inventors:
KOLASA TEODOZYJ
BRIONI JORGE D
GRACIAS VIJAYA
NAKANE MASAKI
PATEL MEENA V
ROHDE JEFFREY
BRIONI JORGE D
GRACIAS VIJAYA
NAKANE MASAKI
PATEL MEENA V
ROHDE JEFFREY
Application Number:
PCT/US2003/006678
Publication Date:
April 01, 2004
Filing Date:
March 04, 2003
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A61P9/00; C07D231/56; C07D401/12; C07D405/12; C07D471/04; (IPC1-7): C07D231/56; A61K31/416; A61K31/4162; A61P9/00; C07D401/12; C07D405/12; C07D471/04
Domestic Patent References:
| WO2000027394A1 | 2000-05-18 | |||
| WO1999058503A1 | 1999-11-18 |
Foreign References:
| EP0745684A1 | 1996-12-04 | |||
| DE19846514A1 | 2000-04-20 |
Other References:
ARAN, VICENTE J. ET AL: "Analogs of cytostatic, fused indazolinones: synthesis, conformational analysis and cytostatic activity against HeLa cells of some 1-substituted indazolols, 2-substituted indazolinones, and related compounds", LIEBIGS ANNALEN (1996), (5), 683-691, XP002246714
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Pharmacological properties of alkyl [ethers] of 1-(m- trifluoromethylphenyl)-3-hydroxy-1H-indazole", XP002246716, accession no. STN Database accession no. 73:64568
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Pharmacological properties of alkyl[ether] derivatives of 1-(p-carbobutoxyphenyl)-3-hydroxy-1H-indazole", XP002246717, accession no. STN Database accession no. 73:23752
TOMINAGA Y ET AL: "Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4@?,3@?:5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-diones and related compounds", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 47, 20 November 1995 (1995-11-20), pages 8641 - 8644, XP004026890, ISSN: 0040-4039
SCHMUTZ ET AL: "Über die Alkylierung von Indazolen", HELVETICA CHIMICA ACTA., vol. 47, no. 7, 1964, VERLAG HELVETICA CHIMICA ACTA. BASEL., CH, pages 1986 - 1996, XP002246715, ISSN: 0018-019X
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Synthesis of some alkyl derivatives of 1-(m-trifluoromethylphenyl)-3- hydroxy-1H-indazole", XP002246719, accession no. STN Database accession no. 70:77855
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Pharmacological properties of alkyl [ethers] of 1-(m- trifluoromethylphenyl)-3-hydroxy-1H-indazole", XP002246716, accession no. STN Database accession no. 73:64568
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Pharmacological properties of alkyl[ether] derivatives of 1-(p-carbobutoxyphenyl)-3-hydroxy-1H-indazole", XP002246717, accession no. STN Database accession no. 73:23752
TOMINAGA Y ET AL: "Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4@?,3@?:5,6]pyrido[2,3-d]pyridazine-5,8(6H,7H)-diones and related compounds", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 47, 20 November 1995 (1995-11-20), pages 8641 - 8644, XP004026890, ISSN: 0040-4039
SCHMUTZ ET AL: "Über die Alkylierung von Indazolen", HELVETICA CHIMICA ACTA., vol. 47, no. 7, 1964, VERLAG HELVETICA CHIMICA ACTA. BASEL., CH, pages 1986 - 1996, XP002246715, ISSN: 0018-019X
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ZONI, GIORGIO ET AL: "Synthesis of some alkyl derivatives of 1-(m-trifluoromethylphenyl)-3- hydroxy-1H-indazole", XP002246719, accession no. STN Database accession no. 70:77855
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