Title:
INDICATOR MOLECULE FOR TOXIGENICITY OF AFLATOXIGENIC FUNGI AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/247927
Kind Code:
A1
Abstract:
The present invention relates to an indicator molecule for the toxigenicity of aflatoxigenic fungi and the use thereof. The amino acid sequence of the indicator molecule ABFT-YJFZ01 for the toxigenicity of the aflatoxigenic fungi is as represented in SEQ ID NO. 1. The indicator molecule is used for identifying the aflatoxin-producing capacity of the Aspergillus aflatoxigenic fungi and identifying whether the aflatoxigenic fungi with high toxigenicity is present in farmland, agricultural products and feed, and is easy to popularize and apply.
Inventors:
LI PEIWU (CN)
ZHANG QI (CN)
BAI YIZHEN (CN)
ZHANG QI (CN)
BAI YIZHEN (CN)
Application Number:
PCT/CN2022/095521
Publication Date:
December 01, 2022
Filing Date:
May 27, 2022
Export Citation:
Assignee:
OIL CROPS RES INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES (CN)
International Classes:
C07K14/38; C07K1/14; C12N1/14; G01N33/577; G01N33/58
Foreign References:
| CN113607949A | 2021-11-05 | |||
| CN113480624A | 2021-10-08 | |||
| CN113607959A | 2021-11-05 | |||
| CN113621676A | 2021-11-09 | |||
| CN113640510A | 2021-11-12 | |||
| CN114097459A | 2022-03-01 | |||
| CN113484512A | 2021-10-08 | |||
| CN103866401A | 2014-06-18 | |||
| CN103849604A | 2014-06-11 |
Other References:
TING HE, YANRU WANG, PEIWU LI , QI ZHANG , JIAWEN LEI , ZHAOWEI ZHANG† , XIAOXIA DING , HAIYAN ZHOU , WEN ZHANG: "Nanobody-based enzyme immunoassay for aflatoxin in agro-products with high tolerance to cosolvent methanol.", ANALYTICAL CHEMISTRY, vol. 86, no. 17, 2 September 2014 (2014-09-02), USA , pages 8873 - 8880, XP002772073, ISSN: 1520-6882, DOI: 10.1021/ac502390c
YANRU WANG, PEIWU LI, ZUZANA MAJKOVA, CANDACE R. S. BEVER, HEE JOO KIM, QI ZHANG, JULIE E. DECHANT, SHIRLEY J. GEE, BRUCE D. HAMMO: "Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay.", ANALYTICAL CHEMISTRY, vol. 85, no. 17, 3 September 2013 (2013-09-03), USA , pages 8298 - 8303, XP002772072, ISSN: 1520-6882, DOI: 10.1021/ac4015885
ZHAO FENGCHUN, TIAN YUAN, SHEN QIANG, LIU RUXIA, SHI RUIRUI, WANG HUIMIN, YANG ZHENGYOU: "A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1", TALANTA, vol. 195, 1 April 2019 (2019-04-01), NL , pages 55 - 61, XP093007706, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2018.11.013
ZHANG XING: "Study on the Distribution,Toxigenicity and Infection of Aspergillus Flavus in Typical Peanut Producing Areas in China", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 June 2019 (2019-06-01), pages 1 - 89, XP093007713
TANG ZAO-XIU, JI RONG-CHANG, LI GUANG-XING, KANG YU-MEI,CHONG ZANG: "Toxigenicity and Pathogenicity of Groundnut A Flavus Strain", FUJIAN JOURNAL OF AGRICULTURAL SCIENCES, vol. 15, no. 2, 30 June 2000 (2000-06-30), pages 19 - 22, XP093007719, ISSN: 1008-0384, DOI: 10.19303/j.issn.1008-0384.2000.02.004
YANRU WANG, PEIWU LI, ZUZANA MAJKOVA, CANDACE R. S. BEVER, HEE JOO KIM, QI ZHANG, JULIE E. DECHANT, SHIRLEY J. GEE, BRUCE D. HAMMO: "Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay.", ANALYTICAL CHEMISTRY, vol. 85, no. 17, 3 September 2013 (2013-09-03), USA , pages 8298 - 8303, XP002772072, ISSN: 1520-6882, DOI: 10.1021/ac4015885
ZHAO FENGCHUN, TIAN YUAN, SHEN QIANG, LIU RUXIA, SHI RUIRUI, WANG HUIMIN, YANG ZHENGYOU: "A novel nanobody and mimotope based immunoassay for rapid analysis of aflatoxin B1", TALANTA, vol. 195, 1 April 2019 (2019-04-01), NL , pages 55 - 61, XP093007706, ISSN: 0039-9140, DOI: 10.1016/j.talanta.2018.11.013
ZHANG XING: "Study on the Distribution,Toxigenicity and Infection of Aspergillus Flavus in Typical Peanut Producing Areas in China", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 June 2019 (2019-06-01), pages 1 - 89, XP093007713
TANG ZAO-XIU, JI RONG-CHANG, LI GUANG-XING, KANG YU-MEI,CHONG ZANG: "Toxigenicity and Pathogenicity of Groundnut A Flavus Strain", FUJIAN JOURNAL OF AGRICULTURAL SCIENCES, vol. 15, no. 2, 30 June 2000 (2000-06-30), pages 19 - 22, XP093007719, ISSN: 1008-0384, DOI: 10.19303/j.issn.1008-0384.2000.02.004
Attorney, Agent or Firm:
HUBEI WUHAN YONGJIA PATENT AGENCY CO., LTD. (CN)
Download PDF: