INDOLE DERIVATIVE-CONTAINING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

INDOLE DERIVATIVE-CONTAINING INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/233669

Kind Code:

A1

Abstract:

The present invention relates to an indole derivative-containing inhibitor, a preparation method therefor and an application thereof, and in particular, to a compound as represented by general formula (Ia), a preparation method therefor, a pharmaceutical composition comprising the compound, and the use thereof in treating related diseases such as cancer, inflammation, chronic liver disease, diabetes, cardiovascular disease, and AIDS as a kinase inhibitor, especially as a receptor tyrosine kinase inhibitor (TKI), more specifically, as an EGFR or HER2 inhibitor. The compound exhibits good inhibitory activity in EGFR and HER2 20 exon mutations.

More Like This:

JP2002508315	INDUSTRIAL APPLICABILITY [Title of Invention] Effective combination for treatment of sexual arousal
WO/1995/013061	PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CANCEROUS DISEASE AND PROCESS FOR THEIR PREPARATION
JP5550151	Use as a medicine to an Indore 3 carbinol analog and its infection

Inventors:

WANG FENG (CN)
DENG HAINING (CN)
SU YIDONG (CN)
CAI JIAQIANG (CN)
BAO RUDI (CN)

Application Number:

PCT/CN2020/091558

Publication Date:

November 26, 2020

Filing Date:

May 21, 2020

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)

International Classes:

A61K31/505; C07D403/04; A61K31/506; A61K31/675; A61P35/00; C07D403/12; C07D405/14; C07D491/10; C07F9/53

Domestic Patent References:

WO2015195228A1	2015-12-23
WO2016054987A1	2016-04-14

Foreign References:

CN108017633A	2018-05-11
CN103702990A	2014-04-02
CN109280048A	2019-01-29
CN106995437A	2017-08-01
CN110652514A	2020-01-07

Other References: