INDOLOMORPHINANE DERIVATIVES AND REMEDIES/PREVENTIVES FOR CEREBRAL DISORDERS

WIPO Patent Application WO/1998/031684

A1

Indolomorphinane derivatives represented by general formula (I) or pharmacologically acceptable acid-addition salts thereof, and remedies/preventives for cerebral disorders containing the same, wherein R?1� represents cyclopropylmethyl, etc.; R?2� and R?3� represent each hydroxy, methoxy, etc.; R?4� represents hydrogen, methyl, benzyl, 3-isothio-cyanatopropyl, etc.; and (R?5�)�m? represents hydrogen, substituted benzo etc. It has been clarified that the above compounds have excellent preventive effects on cranial nerve disorders. Thus, these compounds are useful as drugs for inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders and cranial nerve disorders caused by various nerve degenerations, treating and preventing various cerebral diseases such as cerebral stroke, traumatic cerebral disease, cerebral edema and cranial nerve degeneration disease, ameliorating the after-troubles thereof, and preventing the recurrence thereof.

WO/1994/006426	METHODS FOR IDENTIFYING AND USING LOW/NON-ADDICTIVE OPIOID ANALGESICS
WO/2002/030935	MORPHINOID DERIVATIVES AS DELTA-OPIOID AGONISTS AND ANTAGONISTS
WO/1997/035585	ANESTHETIC METHOD

NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
HIROKAWA JUNICHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)

PCT/JP1998/000092

July 23, 1998

January 13, 1998

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TORAY INDUSTRIES (JP)
NAGASE HIROSHI (JP)
IMAMURA YOSHIFUMI (JP)
HIROKAWA JUNICHI (JP)
MATSUDA SUSUMU (JP)
MIYAUCHI YASUSHI (JP)

C07D489/00; C07D491/18; C07D491/20; (IPC1-7): C07D491/18; A61K31/485

WO1995003308A1	1995-02-02
WO1995003307A1	1995-02-02
WO1994014445A1	1994-07-07

JPH03218313A	1991-09-25
JPS61267517A	1986-11-27
US4816586A	1989-03-28

See also references of EP 0894799A4

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